Original title: Fluorinated Methyl Β-lactosides and Their Multivalent Presentation
Authors: Krčil, Aleš
Document type: Papers
Conference/Event: Bažant Postgraduate Conference 2025, Prague (CZ), 20250617
Year: 2025
Language: eng
Abstract: This work is focused on a full series of mono-deoxyfluorinated methyl β-lactosides, synthesized via glycosylation of methyl glucoside with appropriately protected galactose donors, followed by deprotection. These derivatives are designed for affinity testing with selected human galectins using ELISA. Additionally, a strategy for multivalent ligand presentation is introduced: corresponding β-lactosyl azides were prepared for conjugation onto dendritic scaffolds via click chemistry. These multivalent constructs are useful for studying cluster effects and enhancing binding in lectin–glycan interactions.
Project no.: GA23-05146S (CEP)
Funding provider: GA ČR
Host item entry: Proceedings of Abstracts, ISBN 978-80-86186-35-1

Institution: Institute of Chemical Process Fundamentals AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: https://hdl.handle.net/11104/0367282

Permalink: http://www.nusl.cz/ntk/nusl-680521


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Research > Institutes ASCR > Institute of Chemical Process Fundamentals
Conference materials > Papers