National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Synthesis of Fluorinated Methyl β-Lactosides
Krčil, Aleš
In my contribution, I will describe the synthesis of a complete series of mono-deoxyfluorinated methyl β-lactosides (1–7). Their affinity towards hgals will be determined by analytical method ELISA. The synthesis relies on monosaccharide building blocks, which serves as key intermediates that are transformed into the target products through glycosylation followed by final deprotection steps.
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Synthesis and cytotoxicity of fluorinated mannosamines
Krčil, Aleš
The aim of the project is to synthesise mono-, di- and trifluoroanalogs of N-acetylmannosamines. The cytotoxicity of the final products towards selected cancer cells will be determined. The key intermediates are the corresponding multiply fluorinated mannosazidethioglycosides prepared from deoxyfluorinated 1,6-anhydro-2-azidoβ-D-hexopyranose precursors by ring-opening reactions with phenyltrimethylsilyl sulfide.
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1 Krčil, Adam
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