Název:
A note on the OD-QSSA and Bohl-Marek methods applied to a class of mathematical models
Autoři:
Papáček, Štěpán ; Matonoha, Ctirad Typ dokumentu: Příspěvky z konference Konference/Akce: Programs and Algorithms of Numerical Mathematics /22./, Hejnice (CZ), 20240623
Rok:
2025
Jazyk:
eng
Abstrakt: The complex (bio)chemical reaction systems, frequently possess fast/slow phenomena, represent both diffculties and challenges for numerical simulation. We develop and test an enhancement of the classical QSSA (quasisteady-state approximation) model reduction method applied to a system of chemical reactions. The novel model reduction method, the so-called delayed quasi-steady-state approximation method, proposed by Vejchodsky (2014) and further developed by Papacek (2021) and Matonoha (2022), is extensively presented on a case study based on Michaelis-Menten enzymatic reaction completed with the substrate transport. Eventually, an innovative approach called the Bohl-Marek method is shown on the same numerical example.
Klíčová slova:
chemical kinetic systems; M-Matrix; mathematical modelling; quasi-linear formulation; quasi-steady-state approximation Zdrojový dokument: Programs and Algorithms of Numerical Mathematics 22 : Proceedings of Seminar, ISBN 978-80-85823-74-5