Original title: Determination of the effective charge and ionic mobilities of highly sulfated cyclodextrins by capillary isotachophoresis and zone electrophoresis
Authors: Kašička, Václav ; Šolínová, Veronika ; Sázelová, Petra ; Koval, Dušan ; Vigh, G.
Document type: Papers
Conference/Event: Advances in Chromatography and Electrophoresis & Chiranal 2024, Olomouc (CZ), 20240617
Year: 2024
Language: eng
Abstract: Sulfated cyclodextrins (SCDs) belong to the most popular chiral selectors in capillary electrophoresis [1, 2]. SCDs are available as mixtures of randomly highly sulfated species (HSCDs) or as well defined single isomer compounds (SI-CDs). For the randomly HS-CDs, only an average degree of substitution (DS) is estimated but the isomeric heterogeneity and the charge distribution are not known. In the SI-CDs, the sulfatation positions and the DS are well specified. However, due to close vicinity of the sulfate groups in both types of SCDs, counterion condensation can occur in their molecules and their actual effective charge can be lower than number of sulfate groups. For that reason, the aim of this work was to estimate the degree of charge reduction in both types of SCDs using the procedure based on separation of SCDs and reference compounds by capillary isotachophoresis (CITP) and zone electrophoresis (CZE). \n
Keywords: capillary electrophoresis; capillary isotachophoresis; sulfated cyclodextrins
Host item entry: Advances in Chromatography and Electrophoresis & Chiranal 2024, ISBN 978-80-244-6478-7

Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at external website.
External URL: https://doivup.upol.cz/pdfs/doi/9900/06/7500.pdf
Original record: https://hdl.handle.net/11104/0365810

Permalink: http://www.nusl.cz/ntk/nusl-678763


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