Prostupnost hematoencefalické bariéry při mozkové ischémii

Svoboda, Jan

Permeability of blood brain barrier during cerebral ischemia Abstract Cerebral ischemia remains a leading cause of long-term disability and mortality worldwide, with blood-brain barrier (BBB) dysfunction playing a crucial role in its pathophysiology. This dissertation investigates the mechanisms of BBB permeability changes during ischemic stroke through both clinical and experimental approaches, providing new insights into stroke progression and potential therapeutic interventions. The clinical study involved MRI-based analysis of BBB disruption in ischemic stroke patients during the subacute phase (7-12 days post-stroke). By utilizing advanced imaging techniques, we assessed the localization and extent of BBB impairment in relation to ischemic lesion subregions. The findings indicate a strong correlation between lesion volume and BBB leakage, with significant gadolinium extravasation observed in FLAIR positive regions. The experimental study complemented these findings by employing a middle cerebral artery occlusion (MCAO) model in rodents, closely mimicking clinical stroke conditions and enabling a controlled investigation of BBB permeability changes. By comparing different rat strains, we identified significant variations in cerebrovascular responses, infarct size, and survival rates. Fluorescence...

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