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Original title:
PHYSICAL STABILIZATION OF WATER-SOLUBLE PVA NANOFIBROUS MATERIALS FUNCTIONALIZED WITH BIOLOGICALLY ACTIVE SUBSTANCES
Authors: Lisnenko, M. ; Holeček, M. ; Kuželová Košťáková, E. ; Valtera, J. ; Rejman, Dominik ; Müllerová, J. ; Běhálek, L. ; Jenčová, V.
Document type: Papers
Conference/Event: NANOCON 2023 - International Conference on Nanomaterials - Research & Application /15./, Brno (CZ), 20231018
Year: 2024
Language: eng
Abstract: Tissue engineering aims to develop materials that enhance biological activity and promote tissue healing and regeneration. One promising approach is to functionalize nanofibrous materials with antimicrobial substances, such as lipophosphonoxin (LPPO), and use water-soluble polymers like polyvinyl alcohol (PVA) to incorporate bioactive molecules into fibers. However, water-soluble materials often face the issue of burst release, releasing over 90% of the active substances within the initial 24 hours. This research focuses on preparing functionalized nanofibrous materials based on PVA containing the experimental antimicrobial compound LPPO and subsequent physical stabilization of the materials using the Heat treatment method. The applied stabilization successfully reduced the incorporated substance's release rate by up to 50%. The resulting materials have the potential to provide functional cross-linked PVA nanofiber scaffolds for regenerative medicine applications in large and chronic skin injuries.
Keywords: functionalization; heat treatment; nanofibrous materials; polyvinyl alcohol; tissue engineering
Host item entry: NANOCON Conference Proceedings - International Conference on Nanomaterials, ISBN 978-80-88365-15-0, ISSN 2694-930X
Note: Související webová stránka: https://doi.org/10.37904/nanocon.2023.4793
Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: https://hdl.handle.net/11104/0361684
Permalink: http://www.nusl.cz/ntk/nusl-669200
The record appears in these collections:
Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
Conference materials > Papers
Authors: Lisnenko, M. ; Holeček, M. ; Kuželová Košťáková, E. ; Valtera, J. ; Rejman, Dominik ; Müllerová, J. ; Běhálek, L. ; Jenčová, V.
Document type: Papers
Conference/Event: NANOCON 2023 - International Conference on Nanomaterials - Research & Application /15./, Brno (CZ), 20231018
Year: 2024
Language: eng
Abstract: Tissue engineering aims to develop materials that enhance biological activity and promote tissue healing and regeneration. One promising approach is to functionalize nanofibrous materials with antimicrobial substances, such as lipophosphonoxin (LPPO), and use water-soluble polymers like polyvinyl alcohol (PVA) to incorporate bioactive molecules into fibers. However, water-soluble materials often face the issue of burst release, releasing over 90% of the active substances within the initial 24 hours. This research focuses on preparing functionalized nanofibrous materials based on PVA containing the experimental antimicrobial compound LPPO and subsequent physical stabilization of the materials using the Heat treatment method. The applied stabilization successfully reduced the incorporated substance's release rate by up to 50%. The resulting materials have the potential to provide functional cross-linked PVA nanofiber scaffolds for regenerative medicine applications in large and chronic skin injuries.
Keywords: functionalization; heat treatment; nanofibrous materials; polyvinyl alcohol; tissue engineering
Host item entry: NANOCON Conference Proceedings - International Conference on Nanomaterials, ISBN 978-80-88365-15-0, ISSN 2694-930X
Note: Související webová stránka: https://doi.org/10.37904/nanocon.2023.4793
Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: https://hdl.handle.net/11104/0361684
Permalink: http://www.nusl.cz/ntk/nusl-669200
The record appears in these collections:
Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
Conference materials > Papers
Record created 2025-01-19, last modified 2025-01-19