Struktura minoritních alkaloidů čeledi Amaryllidaceae jako inspirace pro syntézu sloučenin s biologickou aktivitou cílenou vůči Alzheimerově chorobě

Pidaný, Filip

Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmacognosy and Pharmaceutical Botany Candidate: Mgr. Filip Pidaný Supervisor: Prof. Ing. Lucie Cahlíková, Ph.D. Consultant: Assoc. Prof. Jan Korábečný, Ph.D. Title of Doctoral Thesis: The structure of minor alkaloids of the Amaryllidaceae family as inspiration for the synthesis of compounds with biological activity targeting Alzheimer's disease The theoretical part of this dissertation provides a basic overview of the Amaryllidaceae family known for its rich occurrence of structurally diverse alkaloids. These substances exhibit a wide range of pharmacological effects, with our studies focusing on their potential therapeutic use in the treatment of Alzheimer's disease (AD). It is the most common form of dementia, which is characterized by progressive neurodegeneration. As the life expectancy of the population increases, the global prevalence of AD is also rising. This trend presents not only economic but also social challenges for healthcare systems, and society as a whole. The thesis provides detailed descriptions of the most well-known hypotheses of AD development and the characteristics of clinically used medications. Attention is given to the decline in levels of acetylcholinesterase, the dominant enzyme in a healthy...

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