Testování PLGA filmů pro lokální aplikaci kanabidiolu

Juhászová, Daniela

CHARLES UNIVERSITY Faculty of Pharmacy in Hradec Kralove Department of Pharmaceutical Technology Author: Daniela Juhászová Title of thesis: Testing of PLGA films for local delivery of cannabidiol Supervisor: PharmDr. Eva Šnejdrová, PhD. Consultant: PharmDr. Andrea Věříš The aim of the presented work was to study film forming systems for the formation of in situ films (FFS). FFS based on PLGA linear or branched architecture were formulated. The polymers were plasticized with methyl salicylate (MS) or ethyl pyruvate (EP) and incorporated with cannabidiol (CBD). Ethyl acetate, acetone and isopropanol were tested as solvents. In the theoretical section, the general characteristics of the excipients used for the FFS formulation were summarized. In the experimental section, the course of evaporation of the organic solvent from FFS and the effect of the used plasticizer were monitored. The physicochemical properties of the in situ films were characterized using DSC, the SEM method and a tensile test on a rheometer. It was concluded that the solvent evaporation time from FFS is influenced by the used plasticizer, whereas faster solvent evaporation occurred with EP plasticization. DSC showed that the incorporated cannabidiol is dissolved in the in situ film and significantly plasticizes the film. The...

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