Original title: Unique exposure system for the whole body inhalation experiments with small animals
Authors: Večeřa, Zbyněk ; Mikuška, Pavel ; Dočekal, Bohumil ; Vojta, Šimon ; Míšek, Ivan ; Moravec, Pavel ; Smolík, Jiří
Document type: Papers
Conference/Event: NANOCON 2011. International Conference /3./, Brno (CZ), 2011-09-21 / 2011-09-23
Year: 2011
Language: eng
Abstract: The especially inhalation chamber is constructed for chronic exposure studies of small animals to nanoparticles under strictly controlled conditions in frame of project „Study of transport of inhalated nano-sized particles (Pb, Cd) and their allocation in organs“. The inhalation chamber builds from a glass and stainless steel and makes possible long-term inhalation procedures (up to 60 days, 24 hours/day) with up to four discrete groups of mice population (up to 60 individuals each) or of rats population (up to 20 individuals each) under controlled illumination, temperature, relative humidity, doses (0.5 x 106 - 5 x 106 particles/cm3) and size (10-60 nm) of nano-sized particles which are synthesized via aerosol route in a hot wall tube flow reactor using metal organic precursors.
Keywords: chronic exposure studies of small animals; inhalation chamber; long-term inhalation procedures
Project no.: CEZ:AV0Z40310501 (CEP), CEZ:AV0Z40720504 (CEP), CEZ:AV0Z50450515 (CEP), GAP503/11/2315 (CEP)
Funding provider: GA ČR
Host item entry: NANOCON 2011. Conference Proceedings, ISBN 978-80-87294-23-9

Institution: Institute of Analytical Chemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0200160

Permalink: http://www.nusl.cz/ntk/nusl-55957


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