Original title: Polymerase synthesis of modified DNA containing cytosine in major groove
Authors: Kielkowski, Pavel ; Hocek, Michal
Document type: Papers
Conference/Event: Chemistry of Nucleic Acid Components /15./, Český Krumlov (CZ), 2011-06-05 / 2011-06-10
Year: 2011
Language: eng
Abstract: (Cytosine-5-yl)ethynyl derivatives of pyrimidine and 7-deazaadenine 2-deoxyribonucleosides and nucleoside triphosphates (dNTPs) were prepared by aqueous Sonogashira coupling. All modified dNTPs were excellent substrates for DNA polymerases to give DNA bearing acetylene- linked cytosine(s) in the major groove.
Keywords: cytosine; DNA; polymerase
Project no.: CEZ:AV0Z40550506 (CEP), LC512 (CEP), GA203/09/0317 (CEP)
Funding provider: GA MŠk, GA ČR
Host item entry: Chemistry of Nucleic Acid Components. 15th Symposium, ISBN 978-80-86241-37-1

Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0198861

Permalink: http://www.nusl.cz/ntk/nusl-55838


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Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
Conference materials > Papers