Home > Conference materials > Papers > Efficient one-pot synthesis of polysubstituted 6-[(1H-1,2,3-triazol-1-yl)methyl]uracils through the "click" protocol
Original title:
Efficient one-pot synthesis of polysubstituted 6-[(1H-1,2,3-triazol-1-yl)methyl]uracils through the "click" protocol
Authors:
Jansa, Petr ; Špaček, Petr ; Holý, Antonín ; Votruba, Ivan ; Janeba, Zlatko Document type: Papers Conference/Event: Chemistry of Nucleic Acid Components /15./, Český Krumlov (CZ), 2011-06-05 / 2011-06-10
Year:
2011
Language:
eng Abstract:
Synthesis of triazoloacyclic nucleosides and nucleoside phosphonates was developed as the one-pot Cu(I)-catalyzed azide alkyne Huisgen "click" cycloaddition. A novel Cu(I)-catalyzed decarboxylation reaction of 1-substituted 1H-1,2,3-triazole-4-carboxylates at room temperature was observed and used for the preparation of 1-substituted 1H-1,2,3-triazoles.
Keywords:
acyclic nucleoside phosphonates; ANPs; decarboxylation; Huisgen cycloaddition Project no.: CEZ:AV0Z40550506 (CEP), 1M0508 (CEP) Funding provider: GA MŠk Host item entry: Chemistry of Nucleic Acid Components. 15th Symposium, ISBN 978-80-86241-37-1
Institution: Institute of Organic Chemistry and Biochemistry AS ČR
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Document availability information: Fulltext is available at the institute of the Academy of Sciences. Original record: http://hdl.handle.net/11104/0198473