Evoluce viru SARS-CoV-2 během pandemie COVID-19

Karban, Šimon

Coronaviruses are animal and human viruses which, in the case of humans, cause respiratory diseases. The genome of coronaviruses is non-segmented and encodes several structural and several non-structural proteins. As their genome consists of single-stranded RNA in a positive sense, they encode RNA-dependent RNA polymerase. The origin of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is uncertain and may never be known. However, this thesis covers up-to-date knowledge and the arguments for the main theories on the emergence of this virus. The pandemic of disease COVID-19 caused by the SARS-CoV-2 had an enormous impact on the health and lives of people worldwide. The length and severity of the pandemic were caused by the characteristic of the virus, transmissibility and asymptomatic type of infection with severe symptoms in elderly and chronically ill individuals and the fast evolution of the virus after its appearance in humans. This thesis will describe important characteristics of the most important variants of the virus and changes which gave them a selection advantage. In the end, trends in the evolution of SARS-CoV-2 will be discussed. Keywords: SARS-CoV-2, Coronaviridae, variants, phylogeny, origin, evolution

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