Poruchy epigenetické regulace na úrovní modifikací histonů u lymfomů

Hostaš, Ondřej

Lymphomas are a diverse group of malignant tumors that arise from lymphocytes, commonly affecting lymph nodes or the spleen. They are one of the most common types of tumors worldwide. Unfortunately, many subtypes have a poor prognosis, or are not currently fully curable with standard therapeutic approaches. Mutations in enzymes responsible for posttranslational modifications of histones are very common in certain subtypes of lymphoma, as well as in many other cancer types. These enzymes directly affect gene expression by changing the condensation state, and thus the accessibility, of chromatin. Some of these enzymes have been found to play an important role in the formation of germinal centers in lymphoid follicles. Therefore, their mutations can lead to uncontrolled proliferation and cancer development. Since many conventional therapeutic strategies are incapable of curing a large portion of lymphomas, novel and more targeted approaches are needed. Inhibition and/or modulation of the function of the aforementioned enzymes may be a basis for such approaches. Key words: lymphomas, epigenetic regulation, histone modifications, KMT2D, EZH2, CREBBP, EP300

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