Role antigenní prezentace lymfoidních buněk vrozené imunity 3. typu v ustanovení periferní tolerance

Machač, David

Mutual tolerance between organisms is a key evolutionary mechanism for the emergence of commensal and mutualistic relationships. In case of the immune system, the creation of tolerogenic mechanisms towards our own tissues, but also commensal-mutualistic organisms and food antigens, together with defensive components of immunity and their balanced action, is a necessary condition for our survival. To better defend against pathogens, adaptive immunity with randomly assembled TCR and BCR receptors of lymphocytes has evolved. T lymphocytes capable of recognizing the body's own antigens are either deleted (recessive tolerance) or converted to regulatory T cells (Tregs) (dominant tolerance) in the thymic medulla by mechanisms which is collectivelly referred to as central tolerance. Compared to the establishment of central tolerance, the establishment of peripheral tolerance is a more demanding process in terms of the enormous variability of microorganisms living on our mucosal surfaces and skin along with the exposure to a wide variety of food antigens during ontogenesis. It has been shown that innate lymphoid cells expressing the RORγt transcription factor have the ability to present antigens derived from intestinal microorganisms and thus perform the deletion of T lymphocytes recognizing these antigens. These...

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