Original title: Electrochemical Techniques in Monitoring of Nervous System Drugs
Authors: Choińska-Mlynarczyk, Marta ; Hrdlička, Vojtěch ; Skopalová, J. ; Šelešovská, R. ; Kolivoška, Viliam ; Navrátil, Tomáš
Document type: Papers
Conference/Event: Moderní elektrochemické metody /41./, Jetřichovice (CZ), 20220522
Year: 2022
Language: eng
Abstract: Drugs of the nervous system (ATC group N) belong generally to the most commonly (mis)used substances worldwide. Their determination and monitoring of these drugs and their metabolites in various body fluids or environmental matrices represent a challenge for analytical chemists. Our research is focused on the application of electrochemical methods in the monitoring of the most frequently prescribed and the newly introduced nervous system drugs of precisely specified structures and/or of defined properties. For toxicological and pharmacokinetic reasons, emphasis has been placed on investigating the reaction mechanisms of their metabolite formation. New or alternative to commonly used electroanalytical methods applicable for monitoring and characterization of target compounds in their pure state, in body fluids, wastewaters, and other environmental matrices, has been developed. To improve the chemometric parameters and sensing characteristics, attention was paid to the construction of new electrochemical sensors, detectors (e.g. screen-printed, 3D printed), or cells, based on (modified/unmodified) traditional or nontraditional materials, preferably usable at the point-of-care.
Keywords: active pharmaceutical ingredient; electrochemistry; metabolites; nervous system drugs
Project no.: GA20-01589S (CEP)
Funding provider: GA ČR
Host item entry: 41. Moderní elektrochemické metody. Sborník přednášek, ISBN 978-80-905221-9-0

Institution: J. Heyrovsky Institute of Physical Chemistry AS ČR (web)
Document availability information: Fulltext is available on demand via the digital repository of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0331813

Permalink: http://www.nusl.cz/ntk/nusl-508617

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Research > Institutes ASCR > J. Heyrovsky Institute of Physical Chemistry
Conference materials > Papers
 Record created 2022-09-28, last modified 2023-12-06

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