Original title: Liberace kyseliny listové z větvených a síťovaných oligoesterových nosičů
Translated title: Folic acid release from branched and crosslinked oligoester carriers
Authors: Hanáková, Pavlína ; Dittrich, Milan (advisor) ; Šnejdrová, Eva (referee)
Document type: Rigorous theses
Year: 2006
Language: cze
Abstract: [cze] [eng]
ABSTRAKT-CZ Bylo prokázáno ,že dobu liberace kyseliny listové z matric z kyseliny poly(DL-mléčné) větvené mannitolem nebo dipentaerytritolem je možno modifikovat vhodnými aditivy v rozmezí od dvou dnů do 45 dní. Proces se zrychluje s koncentrací triethylcitrátu použitého jako plastifikátor oligoesterového nosiče, s podílem větvící složky v molekule nosiče a se stoupající hodnotou pH dissolučního média. Prolongaci uvolňování kyseliny listové je možno dosáhnout vhodným síťovadlem. ABSTRACT-EN In the thesis were demonstrated possibilities for modification of the release period for folic acid incorporated into matrices prepared from poly(DL-lactic acid) branched by mannit or dipentaerythritol. The range of release process duration from two days to 45 days was demonstrated. Process was shortened by increasing concentration of triethylcitrate used as plasticizer of oligoester carrier, the second possibility concentration of branching agent builded into molecule, and the third one was pH of dissolution medium. Prolongation of release of folic acid was achieved by crosslinking agent as additive incorporated into matrices.

Institution: Charles University Faculties (theses) (web)
Document availability information: Available in the Charles University Digital Repository.
Original record: http://hdl.handle.net/20.500.11956/3198

Permalink: http://www.nusl.cz/ntk/nusl-493109


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Universities and colleges > Public universities > Charles University > Charles University Faculties (theses)
Academic theses (ETDs) > Rigorous theses