Název:
Mathematics and Optimal control theory meet Pharmacy: Towards application of special techniques in modeling, control and optimization of biochemical networks
Autoři:
Papáček, Štěpán ; Matonoha, Ctirad ; Duintjer Tebbens, Jurjen Typ dokumentu: Příspěvky z konference Konference/Akce: SNA'21 Seminar on Numerical Analysis Modelling and Simulation of Challenging Engineering Problems (SNA'21 2021), Ostrava (CZ), 20210125
Rok:
2021
Jazyk:
eng
Abstrakt: Similarly to other scienti c domains, the expenses related to in silico modeling in pharmacology need not be extensively apologized. Vis a vis both in vitro and in vivo experiments, physiologically-based pharmacokinetic (PBPK) and pharmacodynamic models represent an important tool for the assessment of drug safety before its approval, as well as a viable option in designing dosing regimens. In this contribution, some special techniques related to the mathematical modeling, control and optimization of biochemical networks are presented on a paradigmatic example of enzyme kinetics.
Klíčová slova:
Biochemical network; Dynamical system; Input-output regulation; Optimization; Systems pharmacology Číslo projektu: GA19-05872S (CEP) Poskytovatel projektu: GA ČR Zdrojový dokument: Proceedings of the SNA'21 Seminar on Numerical Analysis Modelling and Simulation of Challenging Engineering Problems, ISBN 978-80-86407-82-1