Original title: Voltammetric determination of anticancer drug flutamide at screen-printed carbon electrodes
Authors: Vyskočil, V. ; Navrátil, Tomáš ; Barek, J.
Document type: Papers
Conference/Event: Moderní elektrochemické metody /31./, Jetřichovice (CZ), 2011-05-23 / 2011-05-27
Year: 2011
Language: eng
Abstract: Flutamide, 4-nitro-3-trifluoromethyl-isobutylanilide, is the active component of a synthetic nonsteroidal antiandrogen drug, which is commonly used in the treatment of advanced prostate cancer. In this contribution, optimum conditions have been found vor voltammetric determination of flutamide by DC voltammetry (DCV) and differential pulse voltammetry (DPV) at screen-printed carbon electrodes (SPCEs). Under optimum conditions (Britton-Robinson buffer pH 7.0 - methanol (9:1)), linear calibration curves were measure with limits of quantification 6x10(-7) molL(-1) and 8x10(-7) molL(-1) for DCV at SPCEs, respectively. The newly developed methods were successfully applied to the determination of the drug in pharmaceutical formulation Apo-Flutamide (Eulexin tablets).
Keywords: creatine; flutamide; screen-printed carbon electrodes
Project no.: CEZ:AV0Z40400503 (CEP), IAA400400806 (CEP), GAP206/11/1638 (CEP)
Funding provider: GA AV ČR, GA ČR
Host item entry: Sborník přednášek. XXXI. Moderní elektrochemické metody, ISBN 978-80-254-9634-3

Institution: J. Heyrovsky Institute of Physical Chemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0197638

Permalink: http://www.nusl.cz/ntk/nusl-42848


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Research > Institutes ASCR > J. Heyrovsky Institute of Physical Chemistry
Conference materials > Papers