Original title:
Metabolomics Study of the Association between Pancreatic Cancer and Diabetes Mellitus.
Authors:
Michálková, Lenka ; Horník, Štěpán ; Sýkora, Jan ; Habartová, L. ; Setnička, V. Document type: Papers Conference/Event: Magnetic Moments in Central Europe 2019, Prague (CZ), 20190227
Year:
2019
Language:
eng Abstract:
In our study, 1H NMR metabolomics was employed to plasma samples of pancreatic cancer patients, individuals with long-term diabetes mellitus type 2 (lasting more than 5 years) and healthy controls. The NMR analyses were followed by establishing a statistical model based on principal component analysis and discriminant analysis. The aim was to discover differences between these groups and to define a potential biomarker panel. The statistical evaluation of metabolomics-based profiles provided high values of sensitivity and specificity. Subsequently, plasma samples of the risk group, specifically patients with recently diagnosed diabetes mellitus with a duration of <3 years (possible T3cDM), were analysed and the possibility of PC development was predicted. The achieved results showed strong potential of 1H NMR metabolomics to establish a biomarker panel that would facilitate the early diagnosis of PC and the possibility identify diabetic individuals, who are at risk of developing PC.
Keywords:
biomarker panel; nmr metabolomics; pancreatic cancer Host item entry: Book of Abstracts, ISBN 978-80-86186-97-9
Rights: This work is protected under the Copyright Act No. 121/2000 Coll.