Home > Conference materials > Papers > New antiviral agent, 1-(S)-[3-hydroxy-(2-phosphonomethoxy)propyl]-5-azacytosin: esters and base modified derivatives
Original title:
New antiviral agent, 1-(S)-[3-hydroxy-(2-phosphonomethoxy)propyl]-5-azacytosin: esters and base modified derivatives
Translated title:
Nové virostatikum, 1-(S)-[3-hydroxy-(2-phosphonomethoxy)propyl]-5-azacytosin: estery a modifikované baze
Authors:
Krečmerová, Marcela ; Holý, Antonín ; Pískala, Alois ; Andrei, G. ; Snoeck, R. ; Balzarini, J. ; De Clercq, E. Document type: Papers Conference/Event: Symposium on Chemistry of Nucleic Acid Components /14./, Český Krumlov (CZ), 2008-06-08 / 2008-06-13
Year:
2008
Language:
eng Abstract:
[eng][cze] A series of 6-alkyl-HPMP-5azaC was synthesized using ammonia mediated ring-opening reaction of protected HPMP-5-azaC ester followed by condensation reaction with orthoesters and deprotection of ester groups. Introduction of long chain acyl groups to the N4-position was performed using reaction of some acyl chloride (e.g. behenoyl chloride) and appropriate ester of HPMP-5-azaC or its cyclic form.Série 6-alkyl-HPMP-5azaC byla připravena s využitím amoniakem katalyzovaného otevírání kruhu chráněného HPMP-5-azaC esteru, následnou kondenzací s orthoestery a deprotekcí esterových skupin. Zavedení mastných acylových skupin do polohy N4 bylo provedeno pomocí přislušných acyl chloridů reakcí s esterem HPMP-5-azaC nebo jeho cyklickou formou.
Keywords:
antiviral; HPMP-5-azaC; ring-opening Project no.: CEZ:AV0Z40550506 (CEP), 1M0508 (CEP), 1QS400550501 (CEP) Funding provider: GA MŠk, GA AV ČR Host item entry: Chemistry of Nucleic Acid Components, ISBN 978-80-86241-29-6
Institution: Institute of Organic Chemistry and Biochemistry AS ČR
(web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences. Original record: http://hdl.handle.net/11104/0161993