Original title: Structural studies of humanin and its derivatives in the investigation of their neuroprotective role against Alzheimer's disease
Translated title: Strukturální studie humaninu a jeho analogů - neuroprotektivní role a Alzheimerova nemoc
Authors: Benaki, D. ; Zikos, C. ; Evangelou, A. ; Vlassi, M. ; Slaninová, Jiřina ; Livaniou, E. ; Mikros, E. ; Pelecanou, M.
Document type: Papers
Conference/Event: Biologically Active Peptides /10./, Praha (CZ), 2007-04-11 / 2007-04-13
Year: 2007
Language: eng
Abstract: [eng] [cze]
NMR and CD studies on humanin peptides in aqueous solution and in the presence of trifluoroethyl alcohol (TFE) are reported. The findings showed high flexibility in aqueous environment and the ability to adopt a partial helical conformation in the more lipophilic medium of 30% TFE. Popsána NMR a CD studia peptidů typu humaninu ve vodném prostředí a v přítomnosti trifluoroetylalkoholu (TFE). Výsledky ukázaly vysokou flexibilitu ve vodném prostředí a schopnost zaujmout částečně helikální konformaci v lipofilnějším prostředí 30% TFE.
Keywords: humanin; mode of action; neuroprotective activity
Project no.: CEZ:AV0Z40550506 (CEP), ME 872
Funding provider: GA MŠk
Host item entry: Biologically Active Peptides, ISBN 978-80-86241-28-9

Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0156861

Permalink: http://www.nusl.cz/ntk/nusl-38344


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Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
Conference materials > Papers