Biologická aktivita antioxidačních látek v L-6 myoblastech ze svalů potkana

Staňková, Veronika

Charles University in Prague University Roma Tre Faculty of Pharmacy in Hradec Králové Department of Biology Department of Biochemical Sciences Candidate: Veronika Staňková Supervisor: PharmDr. Iva Boušová, Ph.D. Prof. Sandra Incerpi, Prof. Jens Z. Pedersen, Prof. Luciano Saso Title of diploma thesis: Biological activity of antioxidant compounds in L-6 myoblasts from rat skeletal muscles. This work was carried out in the laboratory of physiology at University Roma Tre in Rome, under the supervision of Prof. Sandra Incerpi. The team of this laboratory studies the antioxidants of different structures and evaluates their ability to prevent the production of reactive oxygen species and oxidative stress. The reactive oxygen and nitrogen species play an important role as regulatory mediators of physiological responses. However, they can be also very harmful because they can damage DNA and proteins, cause peroxidation of lipids and injure other biomoleculs. In my work, I tested the antioxidant effect of different polyphenols (baicalein, 5,6-dihydroxyflavone, negletein, mosloflavone, gallic acid and its derivative) in the cell culture (L-6 myoblasts from rat skeletal muscles) and in the in vitro test. The state of oxidative stress was induced by cumene hydroperoxide (generator of cumene hydroperoxide...

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