Original title:
New inhibitors of human betaine-homocysteine S-methyltransferase
Translated title:
Nové inhibitory lidské betain-homocystein S-metyl transferázy
Authors:
Jiráček, Jiří ; Collinsová, Michaela ; Rosenberg, Ivan ; Netušilová, Hana ; Buděšínský, Miloš ; Garrow, T. A. Document type: Papers Conference/Event: Biologically Active Peptides /9./, Praha (CZ), 2005-04-20 / 2005-04-22
Year:
2005
Language:
eng Abstract:
[eng][cze] We synthesized a series of homocysteine analogues with different substituents on sulfur. The IC50 of the most potent inhibitors is in nanomolar range.Syntetisovali jsme celou řadu analogů homocysteinu s různými substituenty na síře. IC50 nejsilnějšího inhibitoru byla v nanomolární oblasti.
Keywords:
BHMT; inhibitor; transition state Project no.: CEZ:AV0Z40550506 (CEP), IAA4055302 (CEP) Funding provider: GA AV ČR Host item entry: Biologically Active Peptides, ISBN 80-86241-26-2
Institution: Institute of Organic Chemistry and Biochemistry AS ČR
(web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences. Original record: http://hdl.handle.net/11104/0114756