Original title: 2',5'-linked oligo-3'-deoxynucleotide chimeras with chiral alpha-hydroxyphosphonate internucleotide linkage: Improvement of hybridisation selectivity toward RNA?
Translated title: Oligo-3'-deoxynukleotidy s chirální alfa-hydroxyfosfonátovou 2',5' internukleotidovou vazbou: zlepšení hybridizační selektivity vůči RNA?
Authors: Králíková, Šárka ; Buděšínský, Miloš ; Liboska, Radek ; Páv, Ondřej ; Rosenberg, Ivan
Document type: Papers
Conference/Event: Chemistry of Nucleic Acid Components /13./, Špindlerův Mlýn (CZ), 2005-09-03 / 2005-09-09
Year: 2005
Language: eng
Abstract: [eng] [cze]
Synthesis and hybridization selectivity of 9-mers 5’-d(GTG ATA TGC)-3’ (T means modified units) containing both hydroxyphosphonate and phosphodiester 2’-5’ internucleotide linkages toward complementary DNA and RNA counterpart were investigated. Byly syntetizovány 9-mery 5’-d(GTG ATA TGC)-3’ (T je modifikovaná jednotka), které obsahovaly jak hydroxyfosfonátové tak fosfodiesterové 2’-5’ internukleotidové vazby a byla zkoumána jejich hybridizační selektivita vůči DNA and RNA.
Keywords: 2'-5' linkage; hydroxyphosphonates; oligonucleotides
Project no.: CEZ:AV0Z40550506 (CEP), IAA4055101 (CEP), GP203/04/P273 (CEP)
Funding provider: GA AV ČR, GA ČR
Host item entry: Chemistry of Nucleic Acid Components, ISBN 80-86241-25-4

Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0111674

Permalink: http://www.nusl.cz/ntk/nusl-32022


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Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
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