Original title: Isosteric phosphonate 3'-O-P-CH2-O-4'C internucleotide linkage: Attempts to get more data on its stereochemistry
Translated title: Isosterní fosfonátová internukleotidová vazba typu 3'-O-P-CH2-O-4'C: Cesta k dalším údajům o její stereochemii
Authors: Točík, Zdeněk ; Barvík, I. ; Buděšínský, Miloš ; Rosenberg, Ivan
Document type: Papers
Conference/Event: Chemistry of Nucleic Acid Components /13./, Špindlerův Mlýn (CZ), 2005-09-03 / 2005-09-09
Year: 2005
Language: eng
Abstract: [eng] [cze]
Synthesis of model thymidine dinucleoside phosphonate containing 3´-O-P-CH2-O-4´C isosteric linkage in 13C-labelled form enabled its NMR conformational description which was further compared with MDS and ab initio studies. Byl připraven modelový thymidinový dinukleosidfosfonát s isosterní 3´-O-P-CH2-O-4´C internukleotidovou vazbou značenou 13C, což umožnilo konformační popis vazby pomocí NMR a jeho následné srovnání s údaji MDS a ab initio studie.
Keywords: isosteric; phosphonate; stereochemistry
Project no.: CEZ:AV0Z40550506 (CEP), GA203/05/0827 (CEP)
Funding provider: GA ČR
Host item entry: Chemistry of Nucleic Acid Components, ISBN 80-86241-25-4

Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0111645

Permalink: http://www.nusl.cz/ntk/nusl-32017


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Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
Conference materials > Papers