Název:
Voltage and frequency dependent block of sodium current in cardiac cells. Comparison of the effect of two antiarrhythmic drugs
Autoři:
Matějovič, P. ; Bahníková, M. ; Pásek, Michal ; Šimurdová, M. ; Šimurda, J. Typ dokumentu: Příspěvky z konference Konference/Akce: Biosignal 2002, Brno (CZ), 2002-06-26 / 2002-06-28
Rok:
2002
Jazyk:
eng
Abstrakt: Ionic currents recorded in voltage clamp experiments on enzymatically isolated rat ventricular myocytes were analyzed with the aim to study the voltage and frequency dependence of sodium current block induced by two antiarrhythmic drugs: ajmaline and propafenone. The levels of block produced by both examined agents were clearly related to membrane voltage. Interestingly, ajmaline, in contrast to propafenone, did not show frequency and use dependent effect. These differences are analyzed.
Klíčová slova:
antiarrhythmic drugs; cardiac cell; sodium current Číslo projektu: CEZ:AV0Z2076919 (CEP) Zdrojový dokument: Analysis of biomedical signals and images, ISBN 80-214-2633-0, ISSN 1211-412X
Instituce: Ústav termomechaniky AV ČR
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Informace o dostupnosti dokumentu:
Dokument je dostupný v příslušném ústavu Akademie věd ČR. Původní záznam: http://hdl.handle.net/11104/0107742