Original title: Změny tělesného složení obézních dětí během redukčního procesu. Studium vybraných kandidátních genů pro obezitu a jejich asociací s antropometrickými a biochemickými parametry.
Translated title: Body composition changes in obese children during the weight reducing programme. The study of selected candidate genes for obesity and their associations with anthropometric and biochemical parameters.
Authors: Zamrazilová, Hana ; Bláha, Pavel (advisor) ; Štich, Vladimír (referee) ; Brdička, Radim (referee)
Document type: Doctoral theses
Year: 2009
Language: cze
Abstract: [cze] [eng]
1. Abstrakt fvod: Prevalenceobezitydosahlab€hemposlednichdvacetilet takov;ichrozmEr&,Zeje bdZnd nazyvtnapandemii.Z hlediskazdravotnichrizik a komplikacis obezitouspojenfchsejako velmi ziyahnyjevifakt,Zetentostoupajicitrendje markantnfiv ddtskdpopulaci.Studieprokazujijasn6 souvislostimezi dasnouobezitoua obezitoupfetrv6vajicido dospdlosti,mnoZstvimviscer6lniho tuku,kardiovaskul6rnimrrrzilq,diabetem2. typu,hypertenziahyperlipidemii. Cile: Zjistit hmotnostnizmdnyazmEnyv tdlesnemsloZeniu ddtiabsolvujicich5-6tydenniledebnd redukdnipobyt. PorovnatmnoZstvitdlesnehotuku stanovendhoantropometrickfmimetodamia metodouDEXA. Zhodnotitvybrandbiochemickda hormonillniparametrycharakterizujicilipidovi a gluk6zovf metabolismusu obdznichddti. PorovnathodnotyIGF-I a IGFBP3 u obdznicha Stihlfchddti.Zjistit vliv polymorfismfiProl0l9Pro, Ser343Sera Gln223Argv genuproLEPRa polymorfismuLeu162Valv genu pro PPARalfana parametrysledovandv prubdhuredukdniho programu. Metodikaa soubor:Do studiebyly zahrnutydEtive vEku7-18 let(345divek,180chlapc&),ktere seridastnily5-6tfdenniholddebndhoredukdnihopobytuv L6debn6Dr. L. Filipav PodEbradech. Sledovanybyly antropologickd,biochemickd,hormon6,lnia genetickdparametry.Statistickii analyzadatbylaprovedenav programechStatistica6.0,NCSS?7aAntropo. Vfsledky: Do5lok... L. Abstrakt Background: Theprevalenceof obesityhasoverthe pasttwentyyearsgrownto suchanextentthat it is now commonlyrefenedto as a pandemic.From the point of view of healthrisks and complicationsconnectedwith obesity,the fact that this increasingtrend is prominenteven in childrenseemsto beveryserious.Thestudieshaveprovedclearrelationsbetweenearlyobesityand obesitypersistinguntil adulthood,the amountof visceralfat, cardiovascularrisks,diabetestype2, hypertensionandhyperlipidemia. Aims: To detect weight changesand body compositionchangesin children during the comprehensive5-6 weekin-patientweightreducingprogramme.To comparethe amountof body fat determinedby anthropomehicmethodsandDEXA method.To evaluateselectedbiochemical and hormonal parametersof lipid and glucosemetabolismsin obesechildren. To detectthe dependenceof anthropometricand biochemicalparameterson polymorphismsprolgl9pro, Ser343SerandGln2?3Argof the LEPRgene,andpolymorphismLeul62Valof theppARalfagene. Results: The study showed significant difftrences in body weight decreasesexpressedin percentagefromtheinitialbodyweightin thegroupof obesegirls(p & 0.001).Girlsthelowestage category(7-9 years)hadsignificantlygreaterweightlossescomparedto theirweightat thestartof theirstay,opposedto girlsin higheragecategories(11-17years,p & 0.05).At thebeginningof...

Institution: Charles University Faculties (theses) (web)
Document availability information: Available in the Charles University Digital Repository.
Original record: http://hdl.handle.net/20.500.11956/31253

Permalink: http://www.nusl.cz/ntk/nusl-295742


The record appears in these collections:
Universities and colleges > Public universities > Charles University > Charles University Faculties (theses)
Academic theses (ETDs) > Doctoral theses