Original title: Receptor-selective enkephalin analogs
Authors: Pencheva, N. ; Barth, Tomislav
Document type: Papers
Conference/Event: Biologically Active Peptides. Conference /6./, Praha (CZ), 1999-04-21 / 1999-04-23
Year: 1999
Language: eng
Abstract: We investigated the opioid profiles of [Cys2]-enkephalin (enk) analogs and [D-Ala2,Leu5]-enkephalyl-Arg (dalargin) in in vitro bioassay system. The results showed that incorporation of hydrophilic Cys(O2NH2)2 into the enk molecule greatly increases the potency and selectivity of the analogs to ë-opioid receptors, while substitution of D-Ala2 and Arg6 into the molecule of [Leu5]-enk, to ć-opioid receptors.
Keywords: enkephalin; peptides; peptidy
Project no.: GA505/94/0740 (CEP), L-637, CEZ:AV0Z4055905 (CEP)
Funding provider: GA ČR, Ministry of Education
Host item entry: Biologically Active Peptides

Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0089372

Permalink: http://www.nusl.cz/ntk/nusl-28288


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Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
Conference materials > Papers