Original title:
Receptor-selective enkephalin analogs
Authors:
Pencheva, N. ; Barth, Tomislav Document type: Papers Conference/Event: Biologically Active Peptides. Conference /6./, Praha (CZ), 1999-04-21 / 1999-04-23
Year:
1999
Language:
eng Abstract:
We investigated the opioid profiles of [Cys2]-enkephalin (enk) analogs and [D-Ala2,Leu5]-enkephalyl-Arg (dalargin) in in vitro bioassay system. The results showed that incorporation of hydrophilic Cys(O2NH2)2 into the enk molecule greatly increases the potency and selectivity of the analogs to ë-opioid receptors, while substitution of D-Ala2 and Arg6 into the molecule of [Leu5]-enk, to ć-opioid receptors.
Keywords:
enkephalin; peptides; peptidy Project no.: GA505/94/0740 (CEP), L-637, CEZ:AV0Z4055905 (CEP) Funding provider: GA ČR, Ministry of Education Host item entry: Biologically Active Peptides
Institution: Institute of Organic Chemistry and Biochemistry AS ČR
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Document availability information: Fulltext is available at the institute of the Academy of Sciences. Original record: http://hdl.handle.net/11104/0089372