Original title: Determination of enantiopurity of new types of acyclic nucleoside phosphonates by capillary electrophoresis with cyclodextrins-based chiral selectors
Authors: Šolínová, Veronika ; Kaiser, Martin Maxmilian ; Lukáč, Miloš ; Janeba, Zlatko ; Kašička, Václav
Document type: Papers
Conference/Event: Advances in Chromatography and Electrophoresis & Chiranal 2014, Olomouc (CZ), 2014-02-10 / 2014-02-14
Year: 2014
Language: eng
Abstract: Capillary electrophoresis with neutral and cationic cyclodextrins as chiral selectors was applied for determination of enantiopurity analysis of new types of six acyclic nucleoside phosphonates, nucleotide analogues bearing ((3-hydroxypropan-2-yl)-1H-1,2,3-triazol-4-yl)phosphonic acid, 2-((diisopropoxyphosphonyl)methoxy)propanoic acid or 2 (phosphonomethoxy)propanoic acid moieties attached to adenine, guanine, 2,6-diaminopurine, uracil and 5-bromouracil nucleobases. All these compounds were found to be synthesized in pure enantiomeric forms. Employing the UV-absorption detection at 206 nm, their detection limits were in the low micromolar level.
Keywords: acyclic nucleoside phosphonates; capillary electrophoresis; enantiopurity analysis
Project no.: GAP206/12/0453 (CEP), GA13-17224S (CEP), VG20102015046 (CEP)
Funding provider: GA ČR, GA ČR, GA MV
Host item entry: Acta Universitatis Palackianae Olomucensis. Facultas Rerum Naturalium. Chemica 51S, ISBN 978-80-244-3950-1, ISSN 0232-0061

Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0235088

Permalink: http://www.nusl.cz/ntk/nusl-187444


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