Název:
Novel conformationally locked nucleosides and nucleotides
Autoři:
Nencka, Radim ; Šála, Michal ; Hřebabecký, Hubert ; Procházková, Eliška ; Mackman, R. ; Barauskas, O. ; Lee, Y. J. ; Tian, Y. Typ dokumentu: Příspěvky z konference Konference/Akce: Symposium on Chemistry of Nucleic Acid Components /16./, Český Krumlov (CZ), 2014-06-08 / 2014-06-13
Rok:
2014
Jazyk:
eng
Abstrakt: We report on a synthesis of two novel types of conformationally locked nucleoside analogues. We prepared 7 membered ring 3’,5’-bridged nucleoside analogs locked in a Southern conformation. These nucleoside analogues were converted in one pot to appropriate phosphoramidate prodrugs using boronate methodology. We also devised and prepared a novel carbocyclic nucleoside by replacing furanose with cyclohexene that resulted in a locked Northern conformation similar to LNA monomers. Further details on the biological activity and application for oligonucleotide synthesis will be discussed in detail.
Klíčová slova:
locked nucleoside analogues; oligonucleotide synthesis Číslo projektu: GPP207/12/P625 (CEP), VG20102015046 (CEP) Poskytovatel projektu: GA ČR, GA MV Zdrojový dokument: Chemistry of Nucleic Acid Components. 16th Symposium, ISBN 978-80-86241-50-0
Instituce: Ústav organické chemie a biochemie AV ČR
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Informace o dostupnosti dokumentu:
Dokument je dostupný v příslušném ústavu Akademie věd ČR. Původní záznam: http://hdl.handle.net/11104/0234281