Original title:
Insights into the mechanism of action of bactericidal lipophosphonoxins
Authors:
Panova, Natalya ; Zborníková, Eva ; Šimák, Ondřej ; Krásný, Libor ; Kolář, M. ; Látal, T. ; Seydlová, G. ; Rejman, Dominik Document type: Papers Conference/Event: Symposium on Chemistry of Nucleic Acid Components /16./, Český Krumlov (CZ), 2014-06-08 / 2014-06-13
Year:
2014
Language:
eng Abstract:
The advantages offered by antibiotics in the treatment of infectious diseases are endangered due to the increase in the number of antibiotic-resistant bacterial strains. This reduces the efficiency of antibiotic treatments and poses a serious health and economical problem. Currently, the need for novel antibiotics is becoming increasingly apparent. Recently, we discovered a series of compounds termed lipophosphonoxins exhibiting selective cytotoxicity towards gram-positive bacterial cells. The attempt to elucidate the mode of action of lipophosphonoxins is presented here.
Keywords:
antibiotics; cytotoxicity; lipophosphonoxins Project no.: TA02010035 (CEP), GP13-18051P (CEP) Funding provider: GA TA ČR, GA ČR Host item entry: Chemistry of Nucleic Acid Components. 16th Symposium, ISBN 978-80-86241-50-0
Institution: Institute of Organic Chemistry and Biochemistry AS ČR
(web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences. Original record: http://hdl.handle.net/11104/0234279