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Original title:
The Synthesis, Surface Modification and Stability of SPIO Nanoparticles for MRI Application
Authors: Kovář, D. ; Fohlerová, Z. ; Malá, A. ; Jiřík, Radovan ; Starčuk jr., Zenon ; Kalina, M. ; Skládal, P.
Document type: Papers
Conference/Event: NANOCON 2013. International Conference /5./, Brno (CZ), 2013-10-16 / 2013-10-18
Year: 2013
Language: eng
Abstract: The biocompatibility and biodegradability of new magnetic resonance imaging (MRI) contrast agents is high-ly desired. The superparamagnetic iron oxide (SPIO) nanoparticles are suitable candidates for these pur-poses. Here the co-precipitation technique for synthesis of monodispersed SPIO nanoparticles is pre-sented. The critical point of the synthesis is core formation and consequent crystal growth. The conditions for core formation (time, temperature, rate of base addition) were optimised. The nanoparticles were stabilised by either silanisation or polymer coating (cationic chitosan, poly-D-Arg, dextran, gelatine, hyaluronic acid). The stability was investigated in physiological pH, different ionic strength solutions, PBS-albumine solution or blood plasma. The biocompatibility was tested in vitro either in the presence of Saccharomyces cerevisiae or erythrocytes suspension. The size and shape was investigated by atomic force microscopy (AFM) and scanning electron microscopy (SEM). The molecular structures of nanoparticles were investigated by FTIR (Fourier transform infrared spectroscopy). The iron cations were determined using the Prussian blue staining test. The stability of nano-particles was investigated by the zeta potential using the method of electrophoretic light scattering (ELS).
Keywords: nanoparticles; surface modifications
Project no.: ED0017/01/01
Funding provider: GA MŠk
Host item entry: NANOCON 2013. 5th International Conference Proceedings, ISBN 978-80-87294-44-4
Institution: Institute of Scientific Instruments AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0228772
Permalink: http://www.nusl.cz/ntk/nusl-170088
The record appears in these collections:
Research > Institutes ASCR > Institute of Scientific Instruments
Conference materials > Papers
Authors: Kovář, D. ; Fohlerová, Z. ; Malá, A. ; Jiřík, Radovan ; Starčuk jr., Zenon ; Kalina, M. ; Skládal, P.
Document type: Papers
Conference/Event: NANOCON 2013. International Conference /5./, Brno (CZ), 2013-10-16 / 2013-10-18
Year: 2013
Language: eng
Abstract: The biocompatibility and biodegradability of new magnetic resonance imaging (MRI) contrast agents is high-ly desired. The superparamagnetic iron oxide (SPIO) nanoparticles are suitable candidates for these pur-poses. Here the co-precipitation technique for synthesis of monodispersed SPIO nanoparticles is pre-sented. The critical point of the synthesis is core formation and consequent crystal growth. The conditions for core formation (time, temperature, rate of base addition) were optimised. The nanoparticles were stabilised by either silanisation or polymer coating (cationic chitosan, poly-D-Arg, dextran, gelatine, hyaluronic acid). The stability was investigated in physiological pH, different ionic strength solutions, PBS-albumine solution or blood plasma. The biocompatibility was tested in vitro either in the presence of Saccharomyces cerevisiae or erythrocytes suspension. The size and shape was investigated by atomic force microscopy (AFM) and scanning electron microscopy (SEM). The molecular structures of nanoparticles were investigated by FTIR (Fourier transform infrared spectroscopy). The iron cations were determined using the Prussian blue staining test. The stability of nano-particles was investigated by the zeta potential using the method of electrophoretic light scattering (ELS).
Keywords: nanoparticles; surface modifications
Project no.: ED0017/01/01
Funding provider: GA MŠk
Host item entry: NANOCON 2013. 5th International Conference Proceedings, ISBN 978-80-87294-44-4
Institution: Institute of Scientific Instruments AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0228772
Permalink: http://www.nusl.cz/ntk/nusl-170088
The record appears in these collections:
Research > Institutes ASCR > Institute of Scientific Instruments
Conference materials > Papers
Record created 2014-01-10, last modified 2021-11-24