Original title:
Design and Synthesis of Helicene like Molecules
Authors:
Bernard, Martin ; Sýkora, Jan ; Storch, Jan Document type: Papers Conference/Event: Symposium on Catalysis /43./, Praha (CZ), 2011-11-07 / 2011-11-08
Year:
2011
Language:
eng Abstract:
Azahelicenes are unique inherently chiral three-dimensional aromatic compounds with high potential in homogenous assymetric catalysis. Their synthesis has many drawbacks and cannot be done in multigram scale so far. Recently, we have developed a route to new type of helicene-like molecules II. Multigram-scale synthesis of model compound where two benzene rings in [6]helicene skeleton are replaced by cyclopentadiene rings was accomplished in three steps. Such molecules have helical structure similar to helicenes, however, lower racemization barrier. Appropriately modified aza-analogues could be suitable catalysts for asymmetric reactions. Therefore, our synthetic approach leading to these compounds will be discussed.
Keywords:
aromatics compounds; catalysis; synthesis Project no.: CEZ:AV0Z40720504 (CEP), GAP207/10/1124 (CEP), TA01010646 (CEP) Funding provider: GA ČR, GA TA ČR Host item entry: Program Book of Abstracts, ISBN 978-80-87351-15-4
Rights: This work is protected under the Copyright Act No. 121/2000 Coll.