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Obesity its causes and cosequences
Ondráčková, Anna ; Vybíral, Stanislav (advisor) ; Kuda, Ondřej (referee)
Obesity is one of the most common health problems in the Word. Over 500 million adults and over 40 million children are obese. The aim of this work is to summarize findings of causes and consequences of this health problem. Even though in some cases only genetic mutations are responsible for obesity for example mutation in ob gene or Prader-Willi syndrome most cases are caused by lifestyle of people -excessive food intake and insufficient physical activity. There are many health problems accompanying obesity. The most serious problems are metabolic syndrome, diabetes mellitus, cardiovascular diseases and cancer. The consequences of obesity are, however, not confined only to health. We can also observe the economic consequences. Financial cost of treatment of obesity and related diseases are estimated in billions of dollars. Pharmacological treatment has so far proved to be ineffective. If drugs are effective, the side effects are so severe that their use is not possible. So far, the adipose tissue hormones that regulate food intake provide the best hope.
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Mesenchymal stem cells and the possibility of their transdifferentiation into insulin producing cells.
Dostálová, Veronika ; Holáň, Vladimír (advisor) ; Čečrdlová, Eva (referee)
Mesenchymal stem cells (MSCs) have been demonstrated in almost all tissues of the body. Their main source is bone marrow and adipose tissue. These cells are multipotent, e.g. they are capable of differentiating into a variety of cell types. They are able to migrate into damaged tissues. Their other relevant property is a specific suppression of imunity. In the body they serve as precursors for specialized cell types and they also participate in formation of specific tissue microenvironment. Their properties represent a great potential in a wide range of clinical therapies. Besides other possible applications they could be used in the therapy of diabetes mellitus type one. During this disease insulin producing -cells are destroyed. MSCs have been used in experimental in vitro and in vivo studies to differentiate into insulin producing cells. However these cells are not able to produce sufficient amounts of insulin to exclude the supportive administration of exogenous insulin. Therefore there is a need for further research in this field of possible therapy.
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The Effect of Bariatric Operations on the Compensation of Diabetes Mellitus
Horáková, Jitka ; Matoulek, Martin (advisor) ; Haluzík, Martin (referee)
This bachelor thesis deals with the problem of obesity and diabetes mellitus in today's society. The theoretical part brings a closer look at the problem of obesity, the complications resulting from it and the possible ways of therapy. Further it discusses the problem of diabetes mellitus and the influence of obesity on diabetes mellitus type 2 that causes serious health complications. The thesis describes the treatment options of the mentioned diseases, especially focusing on lifestyle changes (dietary regimen, physical activity) and bariatric surgery that significantly contributes to weight reduction and reduction of complications risks. The practical part of the thesis deals with the research in this area, comparing a group of diabetic and non-diabetic patients undergoing the bariatric surgery. Furthermore, it focuses on the impact of the bariatric surgery on the compensation of diabetes mellitus. Keywords: obesity, diabetes mellitus, dietary treatment, bariatric operations
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Development of mortality on diabetes mellitus in developed countries, focusing on the Czech Republic
Koňařík, Martin ; Burcin, Boris (advisor) ; Hulíková Tesárková, Klára (referee)
Development of mortality on diabetes mellitus in developed countries, focusing on the Czech Republic Abstract This thesis addresses the development of diabetes mellitus mortality in selected developed countries between 1950 and 2008 and compares this development with the situation in Czechoslovakia, the Czech Republic respectively. This development is analyzed by sex, age and type of diabetes. Furthermore it also deals with diabetes morbidity and the share of diabetes mortality from the total mortality. The main approach used in this thesis is analysis of standardized mortality rates and this analysis was done both for whole long-term time series and time series within each International Classification of Diseases for individual countries. Based on the results, it was found that the development of diabetes mellitus mortality was similar across selected countries. It could be divided into several phases. Differentiation between mortality rates of males and females that occurred during reference period was so significant that mortality rates of females which were always higher had dropped below the rates of males. This effect is called in this thesis as a transition from higher female mortality to higher male mortality and it occurred in different countries at different times and also had variable-length...
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Chronic disorders that occur at elementary schools
Menoušková, Tereza ; Zvírotský, Michal (referee) ; Hanušová, Jaroslava (advisor)
Reces on chronic disorders that occur at elementary schools. It mainly talks about formulation, structure, procedure, analysis of effects, and preventiv of the chronic disorders. Detailed focus is on identifying school children suffering from some chronic diseases such as asthma, diabetes, eczema, or flu. Reports and cooperation on an "Asthma, eczema, diabetes, flu" project were used to detect the suffering children. Both, healthy and sick children cooperate to achieve set goals within the project. Lastly, the matter of this thesis also includes prevention - recommendation to parents, whose children suffer from the diseases mentioned above. Theoretical observations having reference to chronic diseases, structure of reports, methods of evaluating the effects, preparation of the project and recommendation to parents whose children suffer from chronic disease are applied to completed report examination, project implementation, and discussion with parents.
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Analysis of morbidity in Czechia investigating health care provision and take-up in relation to diabetes mellitus
Kocová, Markéta
Analysis of morbidity in Czechia investigating health care provision and take-up in relation to diabetes mellitus Abstract Diabetes mellitus is a life-threatening disease which presents as hyperglycaemia or raised blood glucose. Late detection or a failure to follow treatment guidelines may lead to complications that significantly impact on the sufferer's daily life and require expensive medical treatment. The growing prevalence of this disease, which no longer only affects developed countries, therefore presents enormous risks to health care systems and society as a whole. The aim of this thesis is to analyse the geodemographic characteristics of the current diabetic population in Czechia. Particular attention will be paid to the age of diabetes sufferers, since in Czechia data on this is lacking. In pursuit of this aim the thesis makes use of anonymised data from the largest Czech health insurance company (Czech General Health Insurance). The first part of the thesis looks at diabetes mellitus as a medical condition, concentrating primarily on the basic types of the disease but also considering the potential health complications this disease causes. The theoretical part will discuss the main risk factors of developing the disease, such as genetic predisposition, age, obesity and other potential factors...
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Alternative components in feeding rations for marmosets and tamarins as prevention of macrosomia, diabetes mellitus and stillborn young
Polívková, Martina ; Svobodová, Ivona (advisor) ; Adéla, Adéla (referee)
This thesis evaluates the suitability of food rations in zoos keeping Callitrichidae considering the prevention of macrosomia, diabetes mellitus and stillborn young, and where needed, suggests a change in feed rations.
The feed rations of Callitrichidae in zoos differ greatly and problems can occur with greater amounts of fat and sugars and often also insufficiency of calcium, which can lead to obesity and further health complications.
When performing this thesis, all food rations of the pygmy marmoset (Cebuella pygmaea), the silvery marmoset (Mico argentatus), the cotton-top tamarin (Saguinus oedipus), the emperor tamarin (Saguinus imperator) and the golden lion tamarin (Leontopithecus rosalia) was weighted during five days in the Olomouc zoo, the Plzeň zoo and the Jihlava zoo. The values of the rations were set based on table rates of the individual components stated in the program ZootritionTM (V2.6) and the final values compared with the recommendations stated in EAZA Husbandry Guidelines 3rd edition (2015).
It was found that changes are needed especially with consideration to the food specialization of the different species, presently all species of Callitrichidae are fed the same rations regardless of their food priorities in the wild.
The recommended changes to rations included changing a part of the ration to a ready mixed foodstuff for Callitrichidae to save time and enable a stable ration with good values of calcium and protein, and feed the animals mainly with vegetables rather than fruit, considering the closeness of vegetables to the fruit available in the wild.
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