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Quantification of measurement uncertainty using Monte Carlo
Mareš, Jaroslav ; Šedivá, Soňa (referee) ; Havlíková, Marie (advisor)
This master’s thesis is focused on evaluation of standard uncertanities of measurement by method GUM and Monte Carlo and theirs comparation. In first part of this thesis is made the theoretical analysis of evaluation of measurement uncertanities and proposal of methodology for evaluating uncertainties by Monte Carlo method. In the second part is described direct and indirect measuring of resistance, capacitance and inductance, including evaluation of standard uncertanities of those measurings by GUM and Monte Carlo methods. In the end of this thesis is made comparison of achieved results of spoken methods.
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Investigation of microdeletion syndromes by FISH method
Polejová, Bronislava ; Kočárek, Eduard (advisor) ; Mareš, Jaroslav (referee)
Mikrodeleční syndromy patří k nejčastějším syndromům způsobeným chromozomovými aberacemi. Většina z nich má autozomálně dominantní dědičnost. Podkladem mikrodelečních syndromů jsou většinou tzv. submikroskopické neboli kryptické delece chromozomů. Výzkumy v posledních dvou desetiletích ukázaly, že tyto aberace jsou daleko častější, než se původně předpokládalo. Výskyt každého mikrodelečního syndromu se odhaduje zhruba na 1/10000 novorozenců. Mikrodelece mohou být malého rozsahu, které nejsou zjistitelné běžným cytogenetickým vyšetřením, proto se zpravidla užívá molekulárně biologických nebo molekulárně cytogenetických metod, např. FISR. Diagnostiku mikrodelečních syndromů komplikuje skutečnost, že u většiny z nich pozorujeme výraznou variabilitu fenotypových projevů. Naopak u některých pacientů s typickým fenotypem není mikrodelece chromozomů molekulárně cytogeneticky prokazatelná. Powered by TCPDF (www.tcpdf.org)
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není uveden
Soukup, Viktor ; Babjuk, Marek (advisor) ; Mareš, Jaroslav (referee) ; Novák, Jaroslav (referee)
Immunohistochemical examination of microvascular density can be an additional prognostic factor in patients with superficial urinary bladder carcinoma, nevertheless, more extensive studies need to be carried out. Maximal microvascular density correlated with a recurrence free interval and in a case of bigger group of patients could be statistically significant. The statistical correlation between MVD and a nuclear p53 accumulation is that significant that we assume the p53 importance in the angiogenesis regulation of superficial urinary bladder carcinoma. The p53 positivity in non-tumor mucosa of urinary bladder in patients with superficial bladder cancer correlates with higher risk of tumor recurrence. According to our results the reason of urinary bladder carcinoma multifocality is genetic instability present in the whole urothelium at the time of tumor diagnosis. The PAX5 gene expression is a frequent finding in superficial transitional cell carcinoma of the bladder. From the prognostic point of view, high levels of PAX5 expression seem to be connected with higher recurrence and progression rates. The extent of lamina propria invasion seems to be a clinically relevant prognostic factor for progression of T1 bladder transitional cell carcinoma. Finding T1b tumor is connected with the risk of understaging....
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Study on metabolism of 3-aminobenzanthrone and induction of biotransformation enzymes
Mizerovská, Jana ; Stiborová, Marie (advisor) ; Mareš, Jaroslav (referee) ; Hýsková, Veronika (referee)
CHARLES UNIVERSITY IN PRAGUE FACULTY OF SCIENCE DEPARTMENT OF BIOCHEMISTRY Study on metabolism of 3-aminobenzanthrone and induction of biotransformation enzymes Summary of PhD Thesis RNDr. Jana Mizerovská Supervisor: Prof. RNDr. Marie Stiborová, DrSc. Prague 2010 RNDr. Jana Mizerovská Introduction 1 INTRODUCTION 3-Nitrobenzanthron, precursor of 3-ABA The nitroaromatic 3-nitrobenzanthrone (3-nitro-7H-benz de anthracen-7-one, 3-NBA) occurs in diesel exhaust and in airborne particulate matter(8, 9, 14) . 3-NBA is most likely formed during the atmospheric reaction of benzanthrone with nitrogen oxides, especially in the presence of ozone, or during imperfect burning of diesel. 3-NBA exhibits extremely high mutagenic activity(9, 14) and is also a genotoxic carcinogen causing lung tumors in rats(14) . 3-NBA is also evaluated to be a potential carcinogen for humans(14, 1, 9, 19) . The genotoxicity of 3-NBA was documented by the detection of specific 3-NBA-derived DNA adducts in vitro, in human cell lines and also in vivo in rats and mice(12, 13, 15, 2) . The predominant DNA adducts formed by 3-NBA after its metabolic activation by reduction of the nitro group are 2-(2'-deoxyguanosin-N2 -yl)-3- aminobenzanthrone and N-(2'-deoxyguanosin-8-yl)-3-aminobenzanthrone(9, 14) and these are most probably responsible for the...
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Cortical and Subcortical Mechanisms of Time Perception
Dušek, Petr ; Jech, Robert (advisor) ; Mareš, Jaroslav (referee) ; Bareš, Martin (referee)
Deficits in interval timing have been described in focal brain lesions and in various neuropsychiatric disorders including Parkinson's disease (PD). The aim of this study was to explore brain areas responsible for human time perception and for the timing deficit in PD. We used a time reproduction task (TRT) which consisted of an encoding phase (during which visual stimuli of durations from 5 to 16.6 sec were presented) and a reproduction phase (during which interval durations were reproduced by a button pressing). In our first fMRI study, we used a parametric modulated analysis searching for brain areas with activity, expressed as Blood Oxygenation Level Dependent (BOLD) signal, correlated with the duration of time interval. During the encoding phase, there was a gradual deactivation of the left prefrontal cortex (PFC) and cingulate gyrus. During the reproduction phase, there was a gradual deactivation in precuneus and an accumulation of activity in the left PFC, primary motor area, right caudate and supplementary motor area (SMA). The second study aimed at supporting the role of two of these areas, SMA and precuneus in interval timing by repetitive transcranial magnetic stimulation (rTMS). Accuracy and variability of time estimates were compared before and after rTMS. Accuracy of estimates was not...
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