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National Repository of Grey Literature

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	Imunologické aspekty rozvoje kolorektálního karcinomu na bezmikrobních modelech Vannucci, Luca ; Štěpánková, Renata ; Pospíšil, Miloslav ; Kozáková, Hana ; Tlaskalová, Helena ; Kuldová, Markéta ; Fišerová, Anna Our data support the finding that mild chronic inflammation sustained by commensal flora in the bowel of conventional animals may be the cause of an effective anticancer response by both mucosal and general immunity Detailed record
	Involvement of NK1.1 receptor in GlcNAc8-conjugate in regulation of antibody formation Huliková, Katarína ; Pospíšil, Miloslav ; Svoboda, Jan ; Kuldová, Markéta ; Fišerová, Anna GlcNAc8-glycoconjugates modulates antigen presentation and B lymphocytes antibody production through NK1.1 receptor triggering Detailed record
	GlcNAc8-dendrimer as a ligand of NKR-P1A receptor in effector-target cell interaction and G-protein signaling Svoboda, Jan ; Kuldová, Markéta ; Huliková, Katarína ; Miller, R. G. ; Fišerová, Anna GlcNAc8 glycodendrimer is a specific ligand of rat NKR-P1A receptor isoform. In effector cells triggers the Gq/11 protein-mediated signaling pathway, and induces subsequent changes in tumor microenvironment Detailed record
	Multivalentní glykokonjugáty ve studiu interakce lektinových receptorů NK/NKT buněk Vannucci, Luca ; Pospíšil, Miloslav ; Rossmann, Pavel ; Chernyavskiy, Oleksandr ; Kubínová, Lucie ; Křen, Vladimír ; Luptovcová, Martina ; Svoboda, Jan ; Kuldová, Markéta ; Bezouška, Karel ; Fišerová, Anna The events following the administration of GN8 in vitro, in vivo and ex vivo, lead to increased expression of CD69. The CD69-dependent IFNg production is modulated by co-activation of NKG2D and Ly49 receptors. Glycodendrimers can assist the dissection of activation network of NK/NKT cell lectin-like receptors in rat and murine models Detailed record
	The role of A2A adenosine receptor in NK cell-mediated cytotoxicity Kuldová, Markéta ; Svoboda, Jan ; Kovářů, H. ; Kovářů, F. ; Šplíchal, Igor ; Fišerová, Anna Adenosine receptor, NK cell, immunity systém, cytotoxicity, Salmonella typhimurium, colorectal carcinoma, murine model, newborn pigs model Detailed record
	Multivalentní glykomika v imunoterapii experimentálních nádorů Vannucci, Luca ; Pospíšil, Miloslav ; Krist, Pavel ; Křen, Vladimír ; Huliková, Katarína ; Luptovcová, Martina ; Svoboda, Jan ; Kuldová, Markéta ; Bezouška, Karel ; Rossmann, Pavel ; Difato, Francesco ; Mosca, F. ; Fišerová, Anna Lectin-like receptors can modulate the cytotoxic, regulatory and dendritic cell responses by their interactions. GN8 multivalent glycoconjugates are able to internalize inside and activate NKR-P1 positive cells inducing production of IFN-gamma and expression of CD69. The final effect is a modulation of anticancer immunity with reduction of cancer growth Detailed record
	Rozvoj kolorektálního karcinomu u konvenčních a bezmikrobních potkanů: imunologické a enzymatické aspekty Vannucci, Luca ; Štěpánková, Renata ; Pospíšil, Miloslav ; Kozáková, Hana ; Tlaskalová, Helena ; Kuldová, Markéta ; Fišerová, Anna Environmental conditions cooperate to colorectal carcinogenesis. In an experimental model in the rat was evaluated the impact of the commensal intestinal flora on cancer development, and consequent general variations of the immunity, versus germ-free (GF) conditions. Less and smaller tumors developed in GF rats and a better developed immune response appeared to be able to be elicited in absence of intestinal bacteria Detailed record
	Interakce glykodendrimerů s nádorovým mikroprostředím Pospíšil, Miloslav ; Vannucci, Luca ; Luptovcová, Martina ; Svoboda, Jan ; Huliková, Katarína ; Kuldová, Markéta ; Fišerová, Anna During carcinogenesis and cancer development tissues undergo to important modifications with creation of a specific cancer microenvironment. Locally, the immune system is challenged by tumor-secreted active biological molecules (eg. cytokines, growth factors, NO, lactic acid) that can impair the activation of an effective anticancer response. The use of glycodendrimers targeting immune cells of innate immunity can rescue the activation and stimulate the immune responses, operating through lectin-like receptors. Detailed record
	Úloha sacharidových struktur v NKR-P1 zprostředkované interakci efektorových a cílových buněk Fišerová, Anna ; Svoboda, J. ; Kuldová, Markéta ; Pucová, Alexandra ; Bezouška, Karel ; Pesta, M. ; Vannucci, Luca ; Pospíšil, Miloslav Masking oligosaccharide sequences can assist transformed cells to escape immune surveillance. N-acetyl-glucosamine coated dendrimers have binding affinity for NKR-P1 receptor and can also modify cancer cell glycosylation profile. Effects of treatment on immune cell subpopulations were analyzed in blood, lymphoid tissues and organs, and inside tumor in B16F10 melanoma bearing mice. Treatment enhanced tumor cell immunogenicity, and induced maturation,differentiation and homing of cytotoxic cells to tumor microenvironment. Detailed record

See also: similar author names
3	Kuldová, Marie
3	Kuldová, Michaela

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