Original title: Multivalent glycomimetics in experimental anticancer immunotherapy
Translated title: Multivalentní glykomika v imunoterapii experimentálních nádorů
Authors: Vannucci, Luca ; Pospíšil, Miloslav ; Krist, Pavel ; Křen, Vladimír ; Huliková, Katarína ; Luptovcová, Martina ; Svoboda, Jan ; Kuldová, Markéta ; Bezouška, Karel ; Rossmann, Pavel ; Difato, Francesco ; Mosca, F. ; Fišerová, Anna
Document type: Papers
Conference/Event: Annual Meeting of the European Society for Clinical Investigation /40./, Prague (CZ), 2006-03-15 / 2006-03-18
Year: 2006
Language: eng
Abstract: [eng] [cze]
Lectin-like receptors can modulate the cytotoxic, regulatory and dendritic cell responses by their interactions. GN8 multivalent glycoconjugates are able to internalize inside and activate NKR-P1 positive cells inducing production of IFN-gamma and expression of CD69. The final effect is a modulation of anticancer immunity with reduction of cancer growth Interakce lektinových receptorů ovlivňuje imunitní odpověď cytotoxických, regulačních a dendritických buněk. Glykokonjugáty spouštějí tyto pochody aktivací NKR-P1 pozitivních buněk a následným zvýšením produkce IFNg a expresí CD69 antigenu
Keywords: immunotherapy; lectin-like receptors
Project no.: CEZ:AV0Z50200510 (CEP), CEZ:AV0Z50110509 (CEP), GA524/04/0102 (CEP), IAA500200509 (CEP)
Funding provider: GA ČR, GA AV ČR
Host item entry: European Journal of Clinical Investigation

Institution: Institute of Microbiology AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0140191

Permalink: http://www.nusl.cz/ntk/nusl-36320


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Research > Institutes ASCR > Institute of Microbiology
Conference materials > Papers