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DNA POLYMERASE STOP ASSAY FOR DETECTION OF G-QUADRUPLEXES
Petr, Marek ; Bažantová, Pavla ; Adámik, Matěj ; Kejnovská, Iva ; Dvořáková, Zuzana ; Vorlíčková, Michaela ; Pečinka, Petr ; Brázdová, Marie
In this work we performed DNA polymerase stop assays while using template DNA derived from promoter regions of VEGF and c-Myc proto-oncogenes under variety of experimental conditions. Partial stopping of DNA synthesis along the template strand was observed in the presence of K+ ions due to formation of stable G-quadruplex structures. In contrast, Na+ ions alone were unable to stabilize G-quadruplexes to stop the reaction at their site. These data suggest that K+ and Na+ ions, which are both known to stabilize G-quadruplexes, do this in different manner or extent.
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Olfactory deficiency in neuropsychological diagnostics of Alzheimer's disease
Vaškovicová, Michaela ; Kulišťák, Petr (advisor) ; Dvořáková, Zuzana (referee)
This bachelor thesis is focused on the application of olfactory deficiency in neuropsychological diagnostics of Alzheimer's disease. Firstly, in the theoretical part, the work shortly summarizes current knowledge regarding neuropsychological diagnostics of Alzheimer's disease, with an emphasis on the new diagnostics criteria and usage of various kinds of biomarkers. Furthermore there is thoroughly covered the topic of olfactory deficiency as an early biomarker of Alzheimer's disease, while focusing on olfactometry employing psychophysical subjective tests. The work also stresses out the possibility of cognitive conditionality of some of the smell tests, most prominently the odor identification test. The issue of cognitive demands of smell tests is also further entertained in the research part, where a study of possible cognitive correlates of the Odor Identification test is proposed. For this purpose was chosen the Odor Identification test from the extended set of Sniffin' Sticks and the neuropsychological test battery Uniform Data Set. The main presumed candidates for cognitive correlates of the smell test are tests of language functions, especially the Boston Naming Test measuring naming ability. The research proposed here is based on controlling influence of cognitive deficits on the Odor...
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Religious dimension in the culture of the Czech schools
DVOŘÁKOVÁ, Zuzana
The thesis deals with the religious dimension of life at Czech secularized school. In its theoretical part, using the theoretical sources, it tries to give some information about different conceptions of religion, about the psychology and sociology´s point of view, about the personality of the teacher and school culture as well and shortly about the development of our school system in the history of the Czech Republic. In its practical part it tries to answer the question about the existence of the religious dimension of life at particular Czech school with the research and its analysis.
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Marketing plan of a chosen company
DVOŘÁKOVÁ, Zuzana
The thesis deals with the way of compiling a marketing plan, according to which the company ACR auto, a.s. could build its posiion in a competitive environment. The result of the thesis is to evaluate the current marketing plan and to propose its update for the following period.
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Řízení rozmanitosti v mezinárodním prostředí
Czapran, Tomasz Bronislaw ; Dvořáková, Zuzana (advisor) ; Kleibl, Jiří (referee) ; Vochozka, Marek (referee)
The dissertation thesis deals with the issues of diversity management in multicultural environment. The primary objective of the thesis is to create a graphical model of diversity management for multicultural organisations operating in the field of information technology. The secondary objective is to identify, through expert literature research, the current approaches to diversity management and to clarify its benefits. The theme is examined and discussed from theoretical as well as practical point of view. The theoretical part deals with the scope, categories, instruments, models and concepts of diversity, as well as diversity management with equal opportunities in the workplace. This section was created not only on the basis of expert literature, but also on the basis of inputs found in impacted and reviewed journals and articles. The practical part presents the quantitative and qualitative research carried out among managers in 14 selected enterprises applying diversity management in varying degrees. Based on this qualitative research hypotheses are formed. These hypotheses are subsequently verified by the quantitative research conducted among managers of selected companies. The practical part has empirical character, as it investigates a specific level of application of diversity management in selected IT organisations with multicultural environment. This investigation is carried out using quantitative and qualitative data collection.
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New technologies in training and development
Bednárová, Miroslava ; Dvořáková, Zuzana (advisor) ; Švejcarová, Pavla (referee)
The goal of this thesis is to bring complex outlook on New technologies used in Training and development, directed mainly to public, Training and development specialists and managers who are deciding whether to start using New technologies in their company or not. The thesis shows the beginning of a company training and its evolution, as well as main pros and cons of new forms. The thesis mentions not only descriptive properties of new technologies, but also defines requirements needed for their usage and measurements used to evaluate their contribution.
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Zhodnocení práce Transparency International v České republice
Kubrová, Lucie ; Dvořáková, Zuzana (advisor)
This thesis aims to assess the marketing strategy and HR management done at Transparency International in the Czech Republic and to propose improvements that could help increase the awareness about the organization. To achieve this, the perception of the Czech citizens is evaluated via questionnaire. Afterwards the marketing strategy done in the Czech branch is described based on the interview with the representative of Transparency International. In the end, the individual elements are compared which enables to define improvement recommendations for the organization.
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The Evaluation of Work Motivation of Employees in the Hospitality Industry
Krejčíková, Denisa ; Dvořáková, Zuzana (advisor)
The aim of the Master Thesis is to determine level of motivation of employees of selected hotel in the Czech Republic. The hospitality industry is specific by high demands on human work. Due to these demands, motivated staff can be a significant competitive advantage to the hotel. The objective of the Master Thesis was achieved thank to the questionnaire survey exploring opinions and attitudes of the hotel staff, an interview with the general manager, stories of the employees and a draft of an incentive program. The Thesis also includes SWOT analysis of motivation in the hotel. The survey showed dissatisfaction of employees with wages, good relations with colleagues and stimulating effect of only a few of the provided benefits. General manager of the hotel emphasizes regular feedback, recognition and financial rewards if the goals are achieved. The benefit of the Thesis is the proposed incentive program based on the individualized Cafeteria system of the offered benefits.
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Motivation and Stabilization of Employees in s Small Company
Zejdová, Petra ; Dvořáková, Zuzana (advisor) ; Cetkovský, Pavel (referee)
This Master´s Thesis is focused on two areas of human resource management which are motivation and stabilization of employees and the link between them. The aim of my Master´s Thesis is to analyze the structure and quality of management of employee motivation and stabilization in a particular company through my own questionnaire survey and internal company data collection. The questionnaire survey is mainly focused on identifying motivation profiles of the company's employees and factors that have a positive impact on their job satisfaction. Thanks to analysis, the relevant conclusions and suggestions are made to strengthen or stabilize the company's strengths and reduce their weaknesses in area of motivation and stabilization management. The outputs of my Master´s Thesis can be used by the company management in order to improve the quality of human resources management and stabilize company's employees.
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Position and functions of personnel department in a company
Bobeková, Simona ; Dvořáková, Zuzana (advisor) ; Cetkovský, Pavel (referee)
This master thesis is focused on a position and functions of personnel department in the company adidas ČR s.r.o. The important part of the thesis is analysis of the employees perception of the personnel department in the company and the analysis of feedback on personnel activities. The theoretical part describes the findings about evolution of personnel work and personnel functions, it also provides the knowledge and instructions how to change the role of human resource professionals in organizations in order to meet the competitive challenges of today and tomorrow. The practical part is dealing with the topic of perception of human resources department and it works with the output from feedback on personnel activities in the company. In the thesis, there were used methods of personal interviews with the company managers and on-line questionnaire for the employees. As an output of the thesis, there were identified the opportunities for the improvement of the current perception of the human resources department and its functions together with some recommendations and guidelines for potential changes and improvements.
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