National Repository of Grey Literature 64 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
Atypical forms of employment
Marek, Jan ; Hůrka, Petr (advisor) ; Tomšej, Jakub (referee)
The modern globalized world is developing rapidly thanks to communication technologies. This trend brought about the need for new and atypical jobs and flexible forms of work. National legislations are responsible for allowing such flexibility. These new forms of work as well as atypical jobs make it possible to better reconcile personal and working life and lead to increased labour productivity, which is in the interest of both employees and employers. This is closely related to the concept of flexicurity, which represents the effort to strike balance between the flexibility of labour law relations and the protective function of labour law. This balance is the legislator's goal. However, said goal is challenging to achieve, given the opposite interests of employees and employers. This thesis is divided into four main chapters and subsequent subchapters. The introduction is focused on a general introduction to the topic and objectives of this proposal. The first chapter summarizes the concept of flexicurity and European and Czech efforts to achieve it. Then it proceeds to the description of its implementation in Denmark with advantages and disadvantages of the possible use of this model in the Czech Republic. The second chapter focuses on the definition of the key terms: atypical form of...
A comparison of lethal and maximum tolerated dose of standard acetylcholinesterase reactivators
Žárská, Nikola ; Kovařík, Miroslav (advisor) ; Marek, Jan (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate Bc. Nikola Žárská Supervisor PharmDr. Miroslav Kovařík, Ph.D. Consultant Mgr. Martina Hrabinová Title of Thesis A comparison of lethal and maximum tolerated dose of standard acetylcholinesterase reactivators. Diploma thesis deals with the topic of nerve agents. Specifically, it demonstrates the reactivating effect of oxime HI-6 (at 100 % maximum tolerated dose and 5 % median lethal dose) on the acetylcholinesterase inhibited by sarin. The experiment was carried out in vivo in Balb/c mice. The treatment was administered either with oxime HI-6 alone, in the above- mentioned doses, or in combination with the parasympatholytic atropine. The change in activity of acetylcholinesterase was measured by spectrophotometrically method, modified by the Ellman, in blood and brain. There were no signs of sarin intoxication in mice, that where treated with 100 % maximum tolerated dose of HI-6, in compare to mice treated with atropine only and 5 % median lethal dose of HI-6, where the intoxication was observed. It was founded that after i.m administration of 100 % maximum tolerated dose, the HI-6 concentration reached 500 µM in plasma and 10 µM in brain. This concentration is safe, but for...
A comparison of tacrine - phenothiazine derivatives in the efficacy of cholinesterase inhibition
Pulkrábková, Lenka ; Kovařík, Miroslav (advisor) ; Marek, Jan (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Bc. Lenka Pulkrábková Supervisor: PharmDr. Miroslav Kovařík, Ph.D. Consultant: Mgr. Martina Hrabinová Title of diploma thesis: A comparison of tacrine - phenothiazine derivatives in the efficacy of cholinesterase inhibition Alzheimer's disease (AD) is a progressive fatal neurodegenerative disorder and the most common type of dementia. It is manifested by a variety of neuropsychiatric symptoms such as memory loss, social skills etc. Ethiology and pathogenesis of the disease has a multifactorial character and is not well known. Among the major pathological features belong: presence of neuronal loss, especially loss of cholinergic neurons, extracellular amyloid plaques, intracellular aggregates of hyperphosphorylated tau protein, oxidative stress etc. As AD is influenced by multiple factors, the main strategy in treatment is intervention multiple targets in the brain as well. Such drugs are denoted as multi-target- directed ligands (MTDLs) and they affect different molecular abnormalities of AD. The aim of this diploma thesis was the evaluation of the ability of tacrine- phenothiazine derivatives to inhibit cholinesterases (AChE, BChE). Derivatives with two to five carbons...
A comparison of tacrine - phenothiazine derivatives in the efficacy of cholinesterase inhibition
Pulkrábková, Lenka ; Kovařík, Miroslav (advisor) ; Marek, Jan (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Bc. Lenka Pulkrábková Supervisor: PharmDr. Miroslav Kovařík, Ph.D. Consultant: Mgr. Martina Hrabinová Title of diploma thesis: A comparison of tacrine - phenothiazine derivatives in the efficacy of cholinesterase inhibition Alzheimer's disease (AD) is a progressive fatal neurodegenerative disorder and the most common type of dementia. It is manifested by a variety of neuropsychiatric symptoms such as memory loss, social skills etc. Ethiology and pathogenesis of the disease has a multifactorial character and is not well known. Among the major pathological features belong: presence of neuronal loss, especially loss of cholinergic neurons, extracellular amyloid plaques, intracellular aggregates of hyperphosphorylated tau protein, oxidative stress etc. As AD is influenced by multiple factors, the main strategy in treatment is intervention multiple targets in the brain as well. Such drugs are denoted as multi-target- directed ligands (MTDLs) and they affect different molecular abnormalities of AD. The aim of this diploma thesis was the evaluation of the ability of tacrine- phenothiazine derivatives to inhibit cholinesterases (AChE, BChE). Derivatives with two to five carbons...
Characterization of engineering geological conditions of industrial area of the Synthos company in Kralupy nad Vltavou
Studenec, Ján ; Rout, Jiří (advisor) ; Marek, Jan (referee)
In my diploma thesis, I concern with the detailed geological model of the base of the industrial complex in Kralupy nad Vltavou and the surrounding area. I have collected all available data from geology, engineering, geology, hydrogeology and geophysics. I created a database and using the autoCAD civil3D software and knowledge from the research part of this work I created a 3D model of interest area. From this model, I created maps and characteristic profiles. Based on archival research and created profiles, I reviewed the foundation basement of the most important buildings. My work provides complete geological information of this territory within 60 meters supported by all available surveys by 2016.
Graphics Intro 64kB Using OpenGL
Marek, Jan ; Tóth, Michal (referee) ; Milet, Tomáš (advisor)
This bachelor's thesis deals with the creation of a graphics intro with a limited size. It deals with methods used for its creation. The thesis describes methods used for reduction of size of executable files. Among them for example the use of prcedural generation and the use of exe packers. The created graphics intro has a size smaller than 64 kB.
Exploitation of HDMI Interface on Minerva Educational Platform
Marek, Jan ; Čekan, Ondřej (referee) ; Šimek, Václav (advisor)
The aim of this thesis is to explore the possibilities of video transfer via HDMI interface. Based on the results a circuit driver TFP410 will be designed, and both the circuit driver and generator of video data for this circuit will be implemented. The target platform in this thesis is school learning developing kit Minerva with MCU Freescale (NXP) Kinetis K60and FPGA Xilinx Spartan 6. The designed solution of the controller is a device controller which transfers communication from MCU to HDMI/DVI digital transmitter TI TFP410. MCU communicates with the device controller over FlexBus. All communication between the transmitter and the controller is realized over I2C bus. The device controller interface and MCU driver library must provide easy usage. The functionality of both the controller and MCU library is demonstrated on two demo applications (games Tetris and Sokoban).
Implementation of Structural Funds in Region Frýdlant, Comparison with Finland
Marek, Jan ; Háva, Petr (advisor) ; Kotlas, Petr (referee)
In recent years, the Structural Funds have been a very common phrase, which for many means hope and expectation of EU assistance, others use this phrase as a political instrument or as a lure for voters, and only a handful of scholars who already have the experience of EU funds, is perceived by the Structural Funds As a complicated administrative procedure. Structural funds have become an important tool and aid for all levels of government and self-government, as well as for non-profit, non-profit organizations and last but not least for entrepreneurs. Self-assembling priority structural policy objectives lose to reality if the way to achieve them leads through unnecessary administrative obstacles. That is why I focused on the implementation of the Structural Funds as a key factor in the area's ability to receive EU aid. I decided to map the level of experience and the level of readiness of the territory to draw on EU funding and compare it with the information I collected during my yearly studies in Finland, where I conducted a number of identical structured interviews with representatives of the public and business sectors at a level similar to The Frýdlant peninsula. I deliberately wanted to link the issue of SF implementation with the region facing the above-average unemployment and population...
Model of public administration client from the perspective of Unified Foundational Ontology
Marek, Jan ; Řepa, Václav (advisor) ; Hrabě, Pavel (referee)
The thesis deals with possibilities of using Unified Foundational Ontology in modeling the onto-logical model of the public administration client, which was created as a result of the Optimiza-tion of life situations in relation to the Register of Rights and Obligations project. The main aim of this thesis is to extend and propose a modification of the current methodology of modeling the ontological model of the public administration client corresponding to the UFO-A ontology. By analyzing the current methodology and ontological model, it proposes the incorporation of OntoUML, which is based on UFO-A ontology. Its key benefit is the methodology of modeling the ontological model of the public administration client corresponding to the UFO-A ontology. The proposed methodology is presented in a case study.
Pyrazine derivatives as potential drugs V.
Horová, Anna ; Marek, Jan (advisor) ; Holas, Ondřej (referee)
Charles University in Prague, Pharmaceutical Faculty in Hradec Králové Department: Department of Pharmaceutical Chemistry and Drug Control Diplomate: Anna Horová Supervisor: PharmDr. Jan Marek, Ph.D. Title of Diploma Thesis: Pyrazine derivatives as potential drugs V. TBC is a specific world-wide infectious disease, compounded by increased migrations of people, the spread of HIV and the growth of MDR-TB, including extremely resistant strains. Precisely for the growth of MDR-TB resistant mycobacteria the work is focused on the preparation and development of other possible antituberculosis drugs (Pyrazine derivatives). Research into new medications lays emphasis on altering the effects of enzymes important for the vitality of mycobacteria. As part of my diploma thesis, pyrazine derivative modifications of clinical pyrazinamide medications were prepared. PZA is an important part of the short-term TBC treatment, having a sterile effect and the ability to work in an acidic environment and has a significant synergy with rifampicin. The small PZA molecule is a precursor to the pyrazine acid activated by pyrazinamide or nicotinamide. Hydrolysis of PZA in mycobacterial cells create Pyrazinecarboxylic acid (POA). In the experimental part, we have examined the variation molecules pyrazinamide and preparing the...

National Repository of Grey Literature : 64 records found   1 - 10nextend  jump to record:
See also: similar author names
24 MAREK, Jakub
45 MAREK, Jan
17 MAREK, Jiří
11 MAREK, Josef
1 Marek, J.
24 Marek, Jakub
7 Marek, Jaroslav
1 Marek, Jindřich
17 Marek, Jiří
11 Marek, Josef
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