National Repository of Grey Literature 67 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
A comparison of lethal and maximum tolerated dose of standard acetylcholinesterase reactivators
Žárská, Nikola ; Kovařík, Miroslav (advisor) ; Marek, Jan (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate Bc. Nikola Žárská Supervisor PharmDr. Miroslav Kovařík, Ph.D. Consultant Mgr. Martina Hrabinová Title of Thesis A comparison of lethal and maximum tolerated dose of standard acetylcholinesterase reactivators. Diploma thesis deals with the topic of nerve agents. Specifically, it demonstrates the reactivating effect of oxime HI-6 (at 100 % maximum tolerated dose and 5 % median lethal dose) on the acetylcholinesterase inhibited by sarin. The experiment was carried out in vivo in Balb/c mice. The treatment was administered either with oxime HI-6 alone, in the above- mentioned doses, or in combination with the parasympatholytic atropine. The change in activity of acetylcholinesterase was measured by spectrophotometrically method, modified by the Ellman, in blood and brain. There were no signs of sarin intoxication in mice, that where treated with 100 % maximum tolerated dose of HI-6, in compare to mice treated with atropine only and 5 % median lethal dose of HI-6, where the intoxication was observed. It was founded that after i.m administration of 100 % maximum tolerated dose, the HI-6 concentration reached 500 µM in plasma and 10 µM in brain. This concentration is safe, but for...
Translation and analysis of a chapter from the novel The Red Knight by Miles Cameron
Marek, Jan ; Richterová, Jana (advisor) ; Ženíšek, Jakub (referee)
This thesis deals with the translation of a chapter from a book called The Red Knight (2012) from English to Czech. It consists of three parts - the introduction, the theoretical part, the practical part together with the final analysis of phenomena in my translation. In the first part, besides the introduction, there is a summary of the novel as a first part of the fantasy cycle The Traitor Son. The practical part contains a mirror translation of the selected chapter. The theoretical part of this thesis explores some aspects of translation and explains why the translation in the practical part is created the way it is. The reasons for author's choices are based on scholarly literature, but also inspired by different fantasy novel translations. There is also a comparison between various typological differences between Czech and English. The result of this bachelor thesis is an attempt to translate an authentic part of a literary work from English to Czech with a focus on aspects which are essential to the translation.
Atypical forms of employment
Marek, Jan ; Hůrka, Petr (advisor) ; Tomšej, Jakub (referee)
The modern globalized world is developing rapidly thanks to communication technologies. This trend brought about the need for new and atypical jobs and flexible forms of work. National legislations are responsible for allowing such flexibility. These new forms of work as well as atypical jobs make it possible to better reconcile personal and working life and lead to increased labour productivity, which is in the interest of both employees and employers. This is closely related to the concept of flexicurity, which represents the effort to strike balance between the flexibility of labour law relations and the protective function of labour law. This balance is the legislator's goal. However, said goal is challenging to achieve, given the opposite interests of employees and employers. This thesis is divided into four main chapters and subsequent subchapters. The introduction is focused on a general introduction to the topic and objectives of this proposal. The first chapter summarizes the concept of flexicurity and European and Czech efforts to achieve it. Then it proceeds to the description of its implementation in Denmark with advantages and disadvantages of the possible use of this model in the Czech Republic. The second chapter focuses on the definition of the key terms: atypical form of...
A comparison of lethal and maximum tolerated dose of standard acetylcholinesterase reactivators
Žárská, Nikola ; Kovařík, Miroslav (advisor) ; Marek, Jan (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate Bc. Nikola Žárská Supervisor PharmDr. Miroslav Kovařík, Ph.D. Consultant Mgr. Martina Hrabinová Title of Thesis A comparison of lethal and maximum tolerated dose of standard acetylcholinesterase reactivators. Diploma thesis deals with the topic of nerve agents. Specifically, it demonstrates the reactivating effect of oxime HI-6 (at 100 % maximum tolerated dose and 5 % median lethal dose) on the acetylcholinesterase inhibited by sarin. The experiment was carried out in vivo in Balb/c mice. The treatment was administered either with oxime HI-6 alone, in the above- mentioned doses, or in combination with the parasympatholytic atropine. The change in activity of acetylcholinesterase was measured by spectrophotometrically method, modified by the Ellman, in blood and brain. There were no signs of sarin intoxication in mice, that where treated with 100 % maximum tolerated dose of HI-6, in compare to mice treated with atropine only and 5 % median lethal dose of HI-6, where the intoxication was observed. It was founded that after i.m administration of 100 % maximum tolerated dose, the HI-6 concentration reached 500 µM in plasma and 10 µM in brain. This concentration is safe, but for...
A comparison of tacrine - phenothiazine derivatives in the efficacy of cholinesterase inhibition
Pulkrábková, Lenka ; Kovařík, Miroslav (advisor) ; Marek, Jan (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Bc. Lenka Pulkrábková Supervisor: PharmDr. Miroslav Kovařík, Ph.D. Consultant: Mgr. Martina Hrabinová Title of diploma thesis: A comparison of tacrine - phenothiazine derivatives in the efficacy of cholinesterase inhibition Alzheimer's disease (AD) is a progressive fatal neurodegenerative disorder and the most common type of dementia. It is manifested by a variety of neuropsychiatric symptoms such as memory loss, social skills etc. Ethiology and pathogenesis of the disease has a multifactorial character and is not well known. Among the major pathological features belong: presence of neuronal loss, especially loss of cholinergic neurons, extracellular amyloid plaques, intracellular aggregates of hyperphosphorylated tau protein, oxidative stress etc. As AD is influenced by multiple factors, the main strategy in treatment is intervention multiple targets in the brain as well. Such drugs are denoted as multi-target- directed ligands (MTDLs) and they affect different molecular abnormalities of AD. The aim of this diploma thesis was the evaluation of the ability of tacrine- phenothiazine derivatives to inhibit cholinesterases (AChE, BChE). Derivatives with two to five carbons...
A comparison of tacrine - phenothiazine derivatives in the efficacy of cholinesterase inhibition
Pulkrábková, Lenka ; Kovařík, Miroslav (advisor) ; Marek, Jan (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Bc. Lenka Pulkrábková Supervisor: PharmDr. Miroslav Kovařík, Ph.D. Consultant: Mgr. Martina Hrabinová Title of diploma thesis: A comparison of tacrine - phenothiazine derivatives in the efficacy of cholinesterase inhibition Alzheimer's disease (AD) is a progressive fatal neurodegenerative disorder and the most common type of dementia. It is manifested by a variety of neuropsychiatric symptoms such as memory loss, social skills etc. Ethiology and pathogenesis of the disease has a multifactorial character and is not well known. Among the major pathological features belong: presence of neuronal loss, especially loss of cholinergic neurons, extracellular amyloid plaques, intracellular aggregates of hyperphosphorylated tau protein, oxidative stress etc. As AD is influenced by multiple factors, the main strategy in treatment is intervention multiple targets in the brain as well. Such drugs are denoted as multi-target- directed ligands (MTDLs) and they affect different molecular abnormalities of AD. The aim of this diploma thesis was the evaluation of the ability of tacrine- phenothiazine derivatives to inhibit cholinesterases (AChE, BChE). Derivatives with two to five carbons...
Characterization of engineering geological conditions of industrial area of the Synthos company in Kralupy nad Vltavou
Studenec, Ján ; Rout, Jiří (advisor) ; Marek, Jan (referee)
In my diploma thesis, I concern with the detailed geological model of the base of the industrial complex in Kralupy nad Vltavou and the surrounding area. I have collected all available data from geology, engineering, geology, hydrogeology and geophysics. I created a database and using the autoCAD civil3D software and knowledge from the research part of this work I created a 3D model of interest area. From this model, I created maps and characteristic profiles. Based on archival research and created profiles, I reviewed the foundation basement of the most important buildings. My work provides complete geological information of this territory within 60 meters supported by all available surveys by 2016.
Graphics Intro 64kB Using OpenGL
Marek, Jan ; Tóth, Michal (referee) ; Milet, Tomáš (advisor)
This bachelor's thesis deals with the creation of a graphics intro with a limited size. It deals with methods used for its creation. The thesis describes methods used for reduction of size of executable files. Among them for example the use of prcedural generation and the use of exe packers. The created graphics intro has a size smaller than 64 kB.
Exploitation of HDMI Interface on Minerva Educational Platform
Marek, Jan ; Čekan, Ondřej (referee) ; Šimek, Václav (advisor)
The aim of this thesis is to explore the possibilities of video transfer via HDMI interface. Based on the results a circuit driver TFP410 will be designed, and both the circuit driver and generator of video data for this circuit will be implemented. The target platform in this thesis is school learning developing kit Minerva with MCU Freescale (NXP) Kinetis K60and FPGA Xilinx Spartan 6. The designed solution of the controller is a device controller which transfers communication from MCU to HDMI/DVI digital transmitter TI TFP410. MCU communicates with the device controller over FlexBus. All communication between the transmitter and the controller is realized over I2C bus. The device controller interface and MCU driver library must provide easy usage. The functionality of both the controller and MCU library is demonstrated on two demo applications (games Tetris and Sokoban).

National Repository of Grey Literature : 67 records found   1 - 10nextend  jump to record:
See also: similar author names
25 MAREK, Jakub
46 MAREK, Jan
20 MAREK, Jiří
13 MAREK, Josef
1 Marek, J.
25 Marek, Jakub
7 Marek, Jaroslav
1 Marek, Jindřich
20 Marek, Jiří
13 Marek, Josef
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