National Repository of Grey Literature 17 records found  1 - 10next  jump to record: Search took 0.00 seconds. 
Interactions of selected antiretroviral drugs and methylmercury with placental membrane transporters
Ťupová, Lenka ; Čečková, Martina (advisor) ; Fusek, Josef (referee) ; Kacerovský, Marian (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Mgr. Lenka Ťupová Supervisor: doc. PharmDr. Martina Čečková, Ph.D. Title of doctoral thesis: Interactions of selected antiretroviral drugs and methylmercury with placental membrane transporters. Pregnant women are especially in developed countries exposed to high amount of various xenobiotic including environmental pollutants and drugs. Antiretroviral therapy (ART) is administered to HIV positive pregnant women for the purpose of prevention of HIV mother- to-child-transmission. Pharmacokinetics of many antiretrovirals is limited or enhanced by activity of ATP-binding cassette (ABC) or Solute carrier's transporters, of which many are expressed also in placental tissue. ART therapy usually consists of combination of 3 - 4 antiretroviral drugs, thereby leading to higher risk for development of drug-drug interactions on ABC and SLC transporters. In this study we described influence of non-nucleoside reverse transcriptase inhibitors etravirin and rilpivirin on BCRP- and MDR1-mediated transport of tenofovir disoproxil fumarate (TDF) and/or abacavir. Etravirin showed potent inhibition of BCRP transporter significantly changing transport of both, TDF and abacavir, across monolayers of MDCKII-BCRP...
Study of interactions of antiviral drugs with selected placental transporters
Karbanová, Sára ; Štaud, František (advisor) ; Kacerovský, Marian (referee) ; Mladěnka, Přemysl (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Sára Karbanová, MSc. Supervisor: prof. PharmDr. František Štaud, Ph.D. Consultant: doc. PharmDr. Lukáš Červený, Ph.D. Title of Dissertation Thesis: Study of interactions of antiviral drugs with selected placental transporters The backbone of HIV treatment in pregnant women is the combination antiretroviral therapy which effectively suppresses the viral proliferation in maternal blood circulation. One of drugs in this therapy regimen should be a molecule with high placental transfer to assure the prophylaxis of viral transfer to fetus. There is no approved guideline for pharmacotherapy of pregnant women infected with hepatitis C (HCV), however recent evidence suggests that lowering the maternal viral load could correlate with lower likelihood of HCV transmission to the fetus. To assure and further develop the effective and safe pharmacotherapeutic approaches for treatment of HIV and HCV in pregnancy with respect to fetal safety, it is essential to understand mechanisms of placental transfer of anti(retro)viral drugs. In this Dissertation thesis we focused on molecules derived from nucleosides (anti-HIV abacavir, emtricitabine, zidovudine, tenofovir disoproxil fumarate and anti-HCV...
Interactions of selected antiretroviral drugs and methylmercury with placental membrane transporters
Ťupová, Lenka ; Čečková, Martina (advisor) ; Fusek, Josef (referee) ; Kacerovský, Marian (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Mgr. Lenka Ťupová Supervisor: doc. PharmDr. Martina Čečková, Ph.D. Title of doctoral thesis: Interactions of selected antiretroviral drugs and methylmercury with placental membrane transporters. Pregnant women are especially in developed countries exposed to high amount of various xenobiotic including environmental pollutants and drugs. Antiretroviral therapy (ART) is administered to HIV positive pregnant women for the purpose of prevention of HIV mother- to-child-transmission. Pharmacokinetics of many antiretrovirals is limited or enhanced by activity of ATP-binding cassette (ABC) or Solute carrier's transporters, of which many are expressed also in placental tissue. ART therapy usually consists of combination of 3 - 4 antiretroviral drugs, thereby leading to higher risk for development of drug-drug interactions on ABC and SLC transporters. In this study we described influence of non-nucleoside reverse transcriptase inhibitors etravirin and rilpivirin on BCRP- and MDR1-mediated transport of tenofovir disoproxil fumarate (TDF) and/or abacavir. Etravirin showed potent inhibition of BCRP transporter significantly changing transport of both, TDF and abacavir, across monolayers of MDCKII-BCRP...
Study of interactions of antiviral drugs with selected placental transporters
Karbanová, Sára ; Štaud, František (advisor) ; Kacerovský, Marian (referee) ; Mladěnka, Přemysl (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Sára Karbanová, MSc. Supervisor: prof. PharmDr. František Štaud, Ph.D. Consultant: doc. PharmDr. Lukáš Červený, Ph.D. Title of Dissertation Thesis: Study of interactions of antiviral drugs with selected placental transporters The backbone of HIV treatment in pregnant women is the combination antiretroviral therapy which effectively suppresses the viral proliferation in maternal blood circulation. One of drugs in this therapy regimen should be a molecule with high placental transfer to assure the prophylaxis of viral transfer to fetus. There is no approved guideline for pharmacotherapy of pregnant women infected with hepatitis C (HCV), however recent evidence suggests that lowering the maternal viral load could correlate with lower likelihood of HCV transmission to the fetus. To assure and further develop the effective and safe pharmacotherapeutic approaches for treatment of HIV and HCV in pregnancy with respect to fetal safety, it is essential to understand mechanisms of placental transfer of anti(retro)viral drugs. In this Dissertation thesis we focused on molecules derived from nucleosides (anti-HIV abacavir, emtricitabine, zidovudine, tenofovir disoproxil fumarate and anti-HCV...
The clinical application of bioimpedance spectroscopy in polytrauma patients and in pregnant women
Josková, Věra ; Hronek, Miloslav (advisor) ; Kacerovský, Marian (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Mgr. Věra Josková Supervisor: doc. PharmDr. Miloslav Hronek, Ph.D. Title of Doctoral Thesis: The clinical application of bioimpedance spectroscopy in polytrauma patients and in pregnant women Introduction and Objectives: Bioimpedance spectroscopy (BIS) is a non-invasive method determining the amount of body fluids and their distribution into the extracellular (ECW) and intracellular (ICW) space, based on the tissue resistance. It has already been applied in many clinical trials in healthy volunteers and in different groups of patients to assess body composition. Furthermore, it seems to be useful in nutritional counseling. However, in critically ill patients hospitalized in intensive care unit (ICU) or in pregnant women, this method has not been used in routine clinical practice as yet. Both of these groups are characterized by the state of increased body fluids. For this reason, BIS could be applied in respective groups of patients. Hence, the main aims of this doctoral thesis were: 1) to describe in detail the principle and the previous use of BIS; 2) to use the BIS to determine the degree of hyperhydratation of patients with polytrauma (PP), and to evaluate the results with the...
The clinical application of bioimpedance spectroscopy in polytrauma patients and in pregnant women
Josková, Věra ; Hronek, Miloslav (advisor) ; Vlček, Jiří (referee) ; Kacerovský, Marian (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Mgr. Věra Josková Supervisor: doc. PharmDr. Miloslav Hronek, Ph.D. Title of Doctoral Thesis: The clinical application of bioimpedance spectroscopy in polytrauma patients and in pregnant women Introduction and Objectives: Bioimpedance spectroscopy (BIS) is a non-invasive method determining the amount of body fluids and their distribution into the extracellular (ECW) and intracellular (ICW) space, based on the tissue resistance. It has already been applied in many clinical trials in healthy volunteers and in different groups of patients to assess body composition. Furthermore, it seems to be useful in nutritional counseling. However, in critically ill patients hospitalized in intensive care unit (ICU) or in pregnant women, this method has not been used in routine clinical practice as yet. Both of these groups are characterized by the state of increased body fluids. For this reason, BIS could be applied in respective groups of patients. Hence, the main aims of this doctoral thesis were: 1) to describe in detail the principle and the previous use of BIS; 2) to use the BIS to determine the degree of hyperhydratation of patients with polytrauma (PP), and to evaluate the results with the...
Indirect calorimetry application in two different insulin-resistant states - polytrauma and pregnancy
Patková, Anna ; Hronek, Miloslav (advisor) ; Havel, Eduard (referee) ; Kacerovský, Marian (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Mgr. Anna Patková Supervisor: doc. PharmDr. Miloslav Hronek, Ph.D. Title of Doctoral Thesis: Indirect calorimetry application in two different insulin-resistant states - polytrauma and pregnancy Introduction and Objective: Indirect calorimetry is the gold standard for energy expenditure (EE) determination that is currently considered to be the best indicator of individual energy requirements - both in health and in illness. Although polytrauma and pregnancy could seem as two physiologically different states, they are quite similar in metabolic terms. Both in polytrauma and in late pregnancy, catabolism increases energy expenditure and insulin resistance occurs. Not only common characteristics mentioned above distinguish these two groups from healthy individuals and non-pregnant women. The aim of this dissertation was to describe the metabolism of polytrauma patients and healthy pregnant women together with the factors that affect it. Besides energy expenditure, this work focuses on respiratory quotient (RQ; in polytrauma also in relation to indirect prognostic markers), which characterizes nutritional substrate oxidations. In pregnant women, the dissertation is also focused on the...
Indirect calorimetry application in two different insulin-resistant states - polytrauma and pregnancy
Patková, Anna ; Hronek, Miloslav (advisor) ; Havel, Eduard (referee) ; Kacerovský, Marian (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Mgr. Anna Patková Supervisor: doc. PharmDr. Miloslav Hronek, Ph.D. Title of Doctoral Thesis: Indirect calorimetry application in two different insulin-resistant states - polytrauma and pregnancy Introduction and Objective: Indirect calorimetry is the gold standard for energy expenditure (EE) determination that is currently considered to be the best indicator of individual energy requirements - both in health and in illness. Although polytrauma and pregnancy could seem as two physiologically different states, they are quite similar in metabolic terms. Both in polytrauma and in late pregnancy, catabolism increases energy expenditure and insulin resistance occurs. Not only common characteristics mentioned above distinguish these two groups from healthy individuals and non-pregnant women. The aim of this dissertation was to describe the metabolism of polytrauma patients and healthy pregnant women together with the factors that affect it. Besides energy expenditure, this work focuses on respiratory quotient (RQ; in polytrauma also in relation to indirect prognostic markers), which characterizes nutritional substrate oxidations. In pregnant women, the dissertation is also focused on the...
Infection-related Intra-amniotic Complications in Women with Preterm Prelabor Rupture of Membranes
Štěpán, Martin ; Kacerovský, Marian (advisor) ; Ľubušký, Marek (referee) ; Záhumenský, Jozef (referee)
Preterm prelabor rupture of membranes before 37. weeks of gestation (PPROM) is responsible for approximately one third of all preterm deliveries. Infection-related complications in PPROM are represented by the presence of microbial invasion of the amniotic cavity (MIAC), intra-amniotic inflammation (IAI) and histological chorioamnionitis (HCA). The presence of these complications is found in approximately 20-50% of all cases of PPROM and is associated with worse neonatal outcomes. The first specific aim was to evaluate whether maternal serum CRP has a diagnostic value for diagnosis of MIAC and HCA. The study population consisted 386 women. CRP level was the highest in PPROM pregnancies complicated with MIAC and HCA. The second specific aim was to evaluate short-term neonatal outcome in women with PPROM before 34 weeks of gestation. The study population consisted 122 women with PPROM at gestation age 24+0 -34+0 weeks. In neonates was evaluated the influence of MIAC and HCA on neonatal outcome. The presence of both MIAC and HCA increased the risk of early onset sepsis. The third and fourth specific aim was evaluation of an association between periodontal status and infection-related intra-amniotic complications in pregnancies complicated by PPROM and/or evaluation of association between the local...
Sonographic characteristics of the abdomen within 6 weeks following cesarean section
Dosedla, Erik ; Calda, Pavel (advisor) ; Kacerovský, Marian (referee) ; Záhumenský, Jozef (referee)
Caesarean section is one of the most frequently performed surgery in medicine. The Cesarean section scar in the uterus can lead to a number of pathological conditions which affect the women reproductive health. In industrialized countries, this issue relates to at least 30% of women, which means that it is a major medical problem. Ultrasound examination of the uterus after Cesarean section includes some specific features, resulting from the rapidly changing dimensions of the uterus, as well as from patient compliance in early puerperium. When dealing with postpartum complications, it is necessary to know the normal ultrasound findings and the dynamic changes of the uterus during puerperium, so that we can better distinguish between the pathological course and the normal course of puerperium. The clinical significance of ultrasound assessment of uterine size and area of the scar after Caesarean section during the postpartum is not yet adequately described. The knowledge of normal ultrasound findings in the uterus after Caesarean section could be helpful in choosing the right treatment in severe cases. We were watching the clinical outcomes of treatment of abnormal Cesarean section scars after their laparoscopic reconstruction. In our study, we have shown that the examination of uterus in early...

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