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Study of influence of hydrophilic carriers on the solubility of a poorly soluble drug
Veselá, Eliška ; Šklubalová, Zdeňka (advisor) ; Vraníková, Barbora (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Department of Pharmaceutical Technology Supervisor: Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Consultant: Mgr. Jana Brokešová Student: Eliška Veselá Title of Thesis: Study of influence of hydrophilic carriers on the solubility of a poorly soluble drug The aim of this thesis was to enhance the solubility of a poorly soluble model drug meloxicam (MLX) by preparing binary interactive mixtures with hydrophilic carriers by simple mixing and co-milling. The mixtures were characterized for granulometric properties. The dissolution studies were carried out using the USP-4 apparatus assembled with a flow-through powder cell in an open-loop system. The dissolution rate rrel (min-1 ) and the amount of released drug mrel (%) were evaluated. The observable positive effect of carriers was registerred in terms of increasing the dissolution rate and the amount of released drug for both mixed and co-milled mixtures comparing to the raw drug. Mixtures with hypromellose were the exception; the improvement of the monitored parameters was not detected.
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Study of influence of hydrophilic carriers on the solubility of a poorly soluble drug
Veselá, Eliška ; Šklubalová, Zdeňka (advisor) ; Vraníková, Barbora (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Department of Pharmaceutical Technology Supervisor: Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Consultant: Mgr. Jana Brokešová Student: Eliška Veselá Title of Thesis: Study of influence of hydrophilic carriers on the solubility of a poorly soluble drug The aim of this thesis was to enhance the solubility of a poorly soluble model drug meloxicam (MLX) by preparing binary interactive mixtures with hydrophilic carriers by simple mixing and co-milling. The mixtures were characterized for granulometric properties. The dissolution studies were carried out using the USP-4 apparatus assembled with a flow-through powder cell in an open-loop system. The dissolution rate rrel (min-1 ) and the amount of released drug mrel (%) were evaluated. The observable positive effect of carriers was registerred in terms of increasing the dissolution rate and the amount of released drug for both mixed and co-milled mixtures comparing to the raw drug. Mixtures with hypromellose were the exception; the improvement of the monitored parameters was not detected.
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Specifics of Linguistic Aphasia: Case Study
Veselá, Eliška ; Janečka, Martin (advisor) ; Vlčková, Jana (referee)
This Master Thesis deals with a typology of aphasia (Broca's, Wernicke's, conductive, transcortical-motor and sensory) and also with various variables that affect the type of aphasia. The thesis also deals with linguistics specifics of aphasia symptoms (circulation, perseveration, semantic and phonemic paraphasias, agramatism). In a practical part of the thesis, the symptoms of aphasia are observed in particular aphasic patients while their speech has been recorded. An author of the thesis is responsible for the correct citations of all sources used. key words: aphasia; aphasiology; agrammatism; cognitive science; Czech; syntax
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Communication media in the history of communication: processing resources for a multimedial e-learning project
Veselá, Eliška ; Kučerová, Helena (advisor) ; Fonferová, Ľudmila (referee)
This bachelor's thesis is dealing with a processing of materials for multimedia, e-learning project currently being prepared by Vyšší odborná škola informačních služeb (VOŠIS). The project is focused on communication history. This thesis describes a research and a processing of materials for one module of a course - Communication media in communication history. The first section depicts a process of the research and criteria for further sorting of materials. The second section goes into individual media types - their characteristics, emergence and development in time. A list of all sources is presented on the last pages of the thesis, however, metadata description of individual sources is due to its extent stored in Moodle (e-learning platform). Graphic materials forming an appendix of the thesis are stored on a DVD inside of a printed version. Electronic form of an appendix was selected in order to maintain quality of photographs.
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A crime of rape (selected issues)
Veselá, Eliška ; Musil, Jan (advisor) ; Krupička, Jiří (referee)
A crime of rape (selected issues) Abstract The thesis deals with the concept of the crime of rape. The ambition of the graduate was not to give an all-embiscite interpretation of this crime from the point of view of criminal law and criminology, but to deal with the basic characteristics of rape and to respond to a possible change in the current law definition of rape. The introduction to the thesis first presents the basic historical development of this crime. Historical developments are demonstrated on three fictional stories so that the reader of the thesis can better imagine the main changes that have taken place in the area of basic constituent elements of the crime. Another part of the thesis consists of an analysis of the basic constituent elements of the of rape in § 185 of the Criminal Code. The interpretation of the basic constituent elements of this offence, complements the interpretation by legal theory and the interpretation of the Supreme Court and Constitutional Court of the Czech Republic. The following chapter in the thesis deals with the construction of the legal definition of rape as sexual intercourse without expressing voluntary consent. This chapter presents a list of states that legislate the crime of rape as sexual intercourse without consent. The following is an analysis of the...
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Content and structure analysis of Czech material science journals abstracts : Hutnické listy and Ceramics-Silikáty
Veselá, Eliška ; Papík, Richard (advisor) ; Kučerová, Helena (referee)
An abstract is a reduced scholarly document crucial for relevant scientific articles and full text documents selection. Therefore abstracts should briefly and clearly represent the full text content. The aim of this research is to construct proper structure, which would be internationally as well as interdisciplinary applied, primarily within the European Union. The structure used in the research was supposed to be evaluated as the most suitable one by the experts. There were 2 material science journals (100 abstracts from each journal) selected. Those samples were analysed in freeware Weft QDA, designed for content analysis of text documents. Sample abstracts were based on the content analysis resulting data. The samples were evaluated by material science experts in the survey. The most common combination of categories in original abstracts were background, methodology and results. The repsonses of surveys pointed out, that the recommended abstract include all necessary information and exclude the redundant ones.
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Communication media in the history of communication: processing resources for a multimedial e-learning project
Veselá, Eliška ; Kučerová, Helena (advisor) ; Fonferová, Ľudmila (referee)
This bachelor's thesis is dealing with a processing of materials for multimedia, e-learning project currently being prepared by Vyšší odborná škola informačních služeb (VOŠIS). The project is focused on communication history. This thesis describes a research and a processing of materials for one module of a course - Communication media in communication history. The first section depicts a process of the research and criteria for further sorting of materials. The second section goes into individual media types - their characteristics, emergence and development in time. A list of all sources is presented on the last pages of the thesis, however, metadata description of individual sources is due to its extent stored in Moodle (e-learning platform). Graphic materials forming an appendix of the thesis are stored on a DVD inside of a printed version. Electronic form of an appendix was selected in order to maintain quality of photographs.
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Business and cultural specificities of Belgium
Veselá, Eliška ; Müllerová, Františka (advisor) ; Sehnal, Libor (referee)
The theme of my bachelor thesis is the business and cultural specificities of Belgium. The first chapter will introduce the general knowledge of the state, such as geography, history, demography and political system. In the next chapter I'm writing about economic and business characteristics. The last chapter is about culture and life in Belgium, business negotiations and dissimilarities between the Walloons and Flemings, and also about the diversity of Czechs and Belgians, which includes opinions and knowledge of business managers.
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