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Macrocyclic ligands for selective complexation of large cations
Šefčík, Martin ; Kotek, Jan (advisor) ; Vojtíšek, Pavel (referee)
4 Abstract Nowadays, macrocyclic complexes of actinides receive an increasing attention for their potential applications in radiotherapy. It requires significant demands on their thermodynamic and kinetic stability which are particularly influenced by an appropriate choice of a ligand. This Thesis focuses on a synthesis and characterization of two ligands that are potentially applicable for complexation of lanthanum as a model of radioactive actinium. Both ligands are based on a fifteen-membered cycle containing pyridine group, 15-pyN3O2. The first ligand, H4L1, contains two phosphonate pendant arms. The second ligand, H2L2, contains two phosphinate pendant arms. Both compounds were prepared and characterized. Keywords Macrocyclic ligands, large cations, phosphonic acids, phosphinic acids, dissociation constants
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Above-standard healthcare - comparison of Czech Republic with selected countries
Rajmon, Ondřej ; Šámalová, Kateřina (advisor) ; Vojtíšek, Petr (referee)
In 2013, by the decision of Constitutional Court of the Czech Republic, the intention of standard and additional health care being separated was repealed. This led to chaos which, even though it is already long time ago, still remains. As law does not allow for the combination of standard and additional health care, it therefore depends upon health care providers who decide if and how will they provide additional health care. Hence, no option is given to the patient other than to pay full price, which makes it unaffordable for the majority. Dealing with this issue needs cooperation of professional associations, the public and politicians. The question is how to set the system in terms of equity, discrimination, and optimization. To answer this question, we shall get inspired by foreign countries - namely United States, United Kingdom and Germany. The paper will try to comprehensively analyse approaches of the countries to additional health care by using desk research method. The most important country to gain inspiration from, as far as Czech Republic is concerned, is the neighbouring country of Germany. Keywords: health, standard of health care, additional health care, qualitative standards, health policy, funding of health care, health insurance
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Involment of adolescents in entrepreneurship in the Czech republic
Pechoušková, Kateřina ; Šťastná, Jaroslava (advisor) ; Vojtíšek, Petr (referee)
(in English) The theoretical part of this Bachelor Thesis focuses on the option of including the youth into social entrepreneurship in the Czech Republic, as an opportunity for the youth to adopt work habits, and, most of all, acquire experience necessary for integration into their life as a part of society. The Thesis focuses on the positives as well as the possible negatives, that the involvement of youth into the social entrepreneurship could bring. The evaluation was made based on the results of a quantitative research, which consisted of half-structured interviews with social workers, who work as staff in children's homes, half-way homes and lead workers of social businesses.
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Expectations of social workers when entering the profession
Novotná, Lucie ; Vojtíšek, Petr (advisor) ; Kodymová, Pavla (referee)
(in English) The diploma thesis deals with the relation of social workers to social work. It uses interviews to determine what helps social workers deal with stress in their work or what makes them leave from the field of social work to another area. Also, it focuses on how realistic expectations social workers have from a specific post. It means which informations they can get from the study, and entrance interview before starting the job. Data was gained through semi-structured interviews with respondents from different groups. The first group is social workers who graduated in social work, but now they are working in other areas. The second group is social workers with experience in the field of fewer than 4 years. The third group is social workers with experience in the field for more than 10 years. The fourth group is the supervisors. This group was chosen to compare the experience with stressful work between supervisors and social workers. This research shows that social workers are influenced by their expectations from a specific post. The most common reason for a field change was financial reasons or burning out. Klíčová slova (anglicky): social work; profession; social worker; employer; working conditions; expectations; job application
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The impact of manager's education on managing an organization operating in the field of social work
Cabalková, Kateřina ; Vojtíšek, Petr (advisor) ; Šťastná, Jaroslava (referee)
(in English): This diploma thesis focuses on the impact of top manager's education on managing organization. Specifically, it focuses on directors who have studied in the field classified as helping professions and also have experience in managing an organization operating in the field of social work. The entire thesis is divided into two parts - theoretical and practical. The theoretical part introduces a definition of helping profession and presents field of education that a helping worker could study. It also introduces reader the theory of management, from historical development, through introducing management as a management process or as a group of managers. The last chapter of theoretical part presents a theory of management styles, a theory of communication or a theory of intentional influencing through control or support. Aim of the practical part is to find out whether and how education could affect for example manager's crisis management, communication in the organization, employee evaluation, attitude to employees or attitude to clients. A qualitative method was chosen for the research survey, specifically a form of semi-structured in-depth interview. Klíčová slova (anglicky): helping profession, education in helping profession, management, management functions, management styles
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Coordination chemistry of pharmaceuticals
Malová, Zuzana ; Lukeš, Ivan (advisor) ; Vojtíšek, Pavel (referee)
Present methods for diagnosis of neurodegenerative diseases are rather limited and in clinical practise are missing. This thesis is focused on utilization of the positron emission tomography using isotope 64 Cu(II). For the project, two contrast agents were proposed containing ligand for Cu (II) coordination and thioflavine T derivative as fluorescent dye, also as a targeting compound. Structure of the thioflavine T derivative was defined by X-ray structural analysis. The selected fluorescent dye has a high affinity for incipient amyloids and, when bound to their structure, has enhanced fluorescent properties. The proposed ligands are tetraazacyclic. The first one is a diamide, where the thioflavin T derivative is part of a macrocyclic ring. The second selected ligand is linked to the thioflavin T derivative via a linker. Key words: complexes; pharmaceuticals; transition metals
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Cyclam derivatives with coordinating bifunctional groups in 1,8 positions for selective copper(II) complexation
Hörnerová, Alžběta ; Kotek, Jan (advisor) ; Vojtíšek, Pavel (referee)
Copper radionuclides are the object of increasing interest due to their advantageous properties for use in tumor diagnostics (PET, SPECT) and radiotherapy. In order to accomplish the best biodistribution the metal ion needs to be complexed by a suitable ligand attached to a biologically active molecule. The aim of this thesis is the synthesis of asymmetrically disubstituted derivatives of 1,4,8,11-tetraazacyclotetradecan (cyclam) with methylphosphonate and methylphosphinate pendant arms in 1,8 positions. Although the synthesis of designed ligands failed, the obtained knowledge will be used in further approaches of preparation of these compounds. Keywords: radiotherapy, SPECT, PET
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Radiolabeling of aluminum and gallium complexes with radioisotope 18F
Kuncová, Lucie ; Kubíček, Vojtěch (advisor) ; Vojtíšek, Pavel (referee)
The most widely used emitter in positron emission tomography is the fluorine isotope 18 F, which can bind to a number of atoms, and thus allows the formation of imaging agents for positron emission tomography. This work will summarize methods for labeling complexes containing aluminum or gallium as a central cation, which can serve as stable carriers of the positron emitter in a human body. Both of these elements have unique physical and chemical properties suitable for molecular imaging. Therefore the development of complex labeling, their structure, coordination environment and some applications in nuclear medicine will be described here.
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Activation of ferrocene ligands by sandwich complexes of Group 4 metals
Kout, Matyáš ; Štěpnička, Petr (advisor) ; Vojtíšek, Pavel (referee)
This bachelor thesis deals with synthesis, reactivity and characterization of compounds resulting from the reactions of substituted ferrocene ligands with electron- deficient complexes of group 4 transition metals in oxidation state II with the aim of finding experimental conditions for preparation of complexes containing two metal atoms in one molecule. Reactions were performed under inert atmosphere and the products were crystallized. The obtained crystals were subjected to X-ray diffraction analysis and to NMR spectroscopy in order to elucidate molecular structure of the isolated products. Along the way, instability of the prepared compounds towards air oxygen and moisture has surfaced, though it also led to a discovery of several original compounds. Among these, the molecule containing peroxide ligand bonded to zirconocene fragment is worth noting as a fine example of oxygen molecule activation with low oxidative state complexes of transition metals.
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Social work with the indebted client from the point of view of a social worker
Hlavatá, Šárka ; Vojtíšek, Petr (advisor) ; Šťastná, Jaroslava (referee)
The bachelor's thesis deals with social work with an indebted client from the point of view of a social worker who works at debt counseling service. The theoretical part of the work will focus on the definition of indebtedness and related terms, causes of indebtedness, options for debt solutions (execution, insolvency), debt counseling, organizations for indebted clients, used methods of social work, etc. The aim of the research part of the work is to find out how the process of working with clients takes place from the point of view of a social worker of a debt counseling service in Liberecký region. What are the problems in the process of solving debts (insolvency)? What are the competencies of a social worker? This will be researched through qualitative research, interviews with social workers of debt counseling service.
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