Studium střevních transportérů a jejich role v absorpci léčiv

Huličiak, Martin

Charles University, Faculty of Pharmacy in Hradec Kralove Training Workplace Department of Pharmacology and Toxicology Doctoral Degree Program Pharmacology and Toxicology Candidate Mgr. Martin Huliciak Supervisor Assoc. Prof. PharmDr. Lukas Cerveny, PhD. Advisor PharmDr. Ivan Vokral, PhD. Title of Doctoral Thesis Study of intestinal transporters and their role in drug absorption Oral drug administration is a widely accepted method due to its convenience and cost- effectiveness, with the small intestine playing a crucial role in drug absorption, thus affecting bioavailability and serving as a potential site for drug-drug interactions (DDIs). Efflux drug transporters such as P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2), along with metabolizing enzymes such as cytochrome P450 3A4 (CYP3A4) at the intestinal barrier, significantly contribute to DDIs. Risk factors for DDIs include comorbidities, advanced age, and polypharmacotherapy. People living with HIV requiring antiretroviral therapy (ART) are particularly susceptible to DDIs, especially when co-infected with HCV. Antivirals, commonly used in ART and in the treatment of HCV infection, can interact with efflux transporters and CYP enzymes, affecting drug efficacy and safety. Therefore, this study mainly focuses on the DDIs of...

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