Název: Vliv mikronizovaného poloxameru na sypnost a lisovatelnost modelové tabletoviny
Překlad názvu: The influence of micronized poloxamer on the flow and compaction of a model tableting mixture
Autoři: Dunlap, Brooke Alexandra ; Šklubalová, Zdeňka (vedoucí práce) ; Svačinová, Petra (oponent)
Typ dokumentu: Rigorózní práce
Rok: 2023
Jazyk: eng
Abstrakt: Charles University, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical Technology Supervisor: Assoc. Prof. Zdenka Šklubalová, Ph.D. Consultant: Sebastien Bailey Student: Brooke Alexandra Dunlap Title of Thesis: The influence of micronized poloxamer on the flow and compaction of a model tableting mixture Lubricants are an important excipient used in the production of tablets, they facilitate powder flow during manipulation, prevent powder sticking to the press during compression, and aid in tablet ejection. In this thesis the effect of four different concentrations 0.5, 1.0, 1.5, and 2.0 % w/w of micronized Poloxamer 188 on a model tableting mixture consisting of a 1:1 ratio of Microcrystalline Cellulose (MCC) and Lactose (L) was tested to determine its effectiveness as a lubricant for tablet manufacturing. Flow through an orifice, angle of repose, Hausner ratio, compressibility index, dynamics of consolidation, and powder bed porosity were tested. There was no increase in flowability of the powder at any concentration of P188 in any test used, all mixtures showed poor or very poor flow behaviour. Compression process was evaluated according to the force displacement method at three different compression forces (5 kN, 7 kN, 10 kN) and special attention was paid to ejection force. P188 is an...
Klíčová slova: lisovatelnost; lubrikanty; pomocné látky; sypnost; tablety; compressibility; excipients; flowability; lubricants; tablets

Instituce: Fakulty UK (VŠKP) (web)
Informace o dostupnosti dokumentu: Dostupné v digitálním repozitáři UK.
Původní záznam: http://hdl.handle.net/20.500.11956/187070

Trvalý odkaz NUŠL: http://www.nusl.cz/ntk/nusl-537575


Záznam je zařazen do těchto sbírek:
Školství > Veřejné vysoké školy > Univerzita Karlova > Fakulty UK (VŠKP)
Vysokoškolské kvalifikační práce > Rigorózní práce