Original title: Metabolomics Study of the Association between Pancreatic Cancer and Diabetes Mellitus.
Authors: Michálková, Lenka ; Horník, Štěpán ; Sýkora, Jan ; Habartová, L. ; Setnička, V.
Document type: Papers
Conference/Event: Magnetic Moments in Central Europe 2019, Prague (CZ), 20190227
Year: 2019
Language: eng
Abstract: In our study, 1H NMR metabolomics was employed to plasma samples of pancreatic cancer patients, individuals with long-term diabetes mellitus type 2 (lasting more than 5 years) and healthy controls. The NMR analyses were followed by establishing a statistical model based on principal component analysis and discriminant analysis. The aim was to discover differences between these groups and to define a potential biomarker panel. The statistical evaluation of metabolomics-based profiles provided high values of sensitivity and specificity. Subsequently, plasma samples of the risk group, specifically patients with recently diagnosed diabetes mellitus with a duration of <3 years (possible T3cDM), were analysed and the possibility of PC development was predicted. The achieved results showed strong potential of 1H NMR metabolomics to establish a biomarker panel that would facilitate the early diagnosis of PC and the possibility identify diabetic individuals, who are at risk of developing PC.
Keywords: biomarker panel; nmr metabolomics; pancreatic cancer
Host item entry: Book of Abstracts, ISBN 978-80-86186-97-9
Rights: This work is protected under the Copyright Act No. 121/2000 Coll.

Institution: Institute of Chemical Process Fundamentals AS ČR (web)
Original record: http://hdl.handle.net/11104/0295701

Permalink: http://www.nusl.cz/ntk/nusl-394158

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Research > Institutes ASCR > Institute of Chemical Process Fundamentals
Conference materials > Papers
 Record created 2019-04-15, last modified 2019-04-15

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