Název: Combination of cobalt bis(dicarbollide) amino derivative and antibiotic effect on growth of staphylococcus epidermidis
Autoři: Lokočová, K. ; Vaňková, E. ; Šícha, Václav ; Masák, J.
Typ dokumentu: Příspěvky z konference
Konference/Akce: International Conference on Chemical Technology /6./, Mikulov (CZ), 20180416
Rok: 2018
Jazyk: eng
Edice: International Conference on Chemical Technology
Abstrakt: Nosocomial infections are often caused by bacteria from the Staphylococcus genus. The clinically relevant representatives of this species are Staphylococcus epidermidis and Staphylococcus aureus which grow predominantly as surface-attached stable communities known as biofilms. Cells in these biofilms are often highly resistant to antibiotics. Therefore, new antimicrobial or antibiofilm substances are still being developed. In this study, we investigated the influence of cobalt bis(dicarbollide) or its amino derivatives, and antibiotics (erythromycin, tetracycline)-alone and in combination-to determine the antimicrobial activity and the inhibition of biofilm formation against three type strains of S. epidermidis. We used a microcultivation device to determine the minimum inhibitory concentrations and MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay to determine the metabolic activity of the cells in biofilms. We observed the synergistic effect of cobalt bis(dicarbollide) and its amino derivatives with both the antibiotics on both the planktonic and biofilm cells.
Klíčová slova: cobalt bis(dicarbollide); staphylococcus genus
Zdrojový dokument: Proceedings of the 6th International Conference on Chemical Technology, ISBN 978-80-86238-77-7, ISSN 2336-8128

Instituce: Ústav anorganické chemie AV ČR (web)
Informace o dostupnosti dokumentu: Dokument je dostupný na externích webových stránkách.
Externí umístění souboru: https://www.icct.cz/AngiologyKlon-ICCT/media/system/2018/ICCT-2018-Proceedings.pdf
Původní záznam: http://hdl.handle.net/11104/0295557

Trvalý odkaz NUŠL: http://www.nusl.cz/ntk/nusl-394145


Záznam je zařazen do těchto sbírek:
Věda a výzkum > AV ČR > Ústav anorganické chemie
Konferenční materiály > Příspěvky z konference