Original title: Combination of cobalt bis(dicarbollide) amino derivative and antibiotic effect on growth of staphylococcus epidermidis
Authors: Lokočová, K. ; Vaňková, E. ; Šícha, Václav ; Masák, J.
Document type: Papers
Conference/Event: International Conference on Chemical Technology /6./, Mikulov (CZ), 20180416
Year: 2018
Language: eng
Series: International Conference on Chemical Technology
Abstract: Nosocomial infections are often caused by bacteria from the Staphylococcus genus. The clinically relevant representatives of this species are Staphylococcus epidermidis and Staphylococcus aureus which grow predominantly as surface-attached stable communities known as biofilms. Cells in these biofilms are often highly resistant to antibiotics. Therefore, new antimicrobial or antibiofilm substances are still being developed. In this study, we investigated the influence of cobalt bis(dicarbollide) or its amino derivatives, and antibiotics (erythromycin, tetracycline)-alone and in combination-to determine the antimicrobial activity and the inhibition of biofilm formation against three type strains of S. epidermidis. We used a microcultivation device to determine the minimum inhibitory concentrations and MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay to determine the metabolic activity of the cells in biofilms. We observed the synergistic effect of cobalt bis(dicarbollide) and its amino derivatives with both the antibiotics on both the planktonic and biofilm cells.
Keywords: cobalt bis(dicarbollide); staphylococcus genus
Host item entry: Proceedings of the 6th International Conference on Chemical Technology, ISBN 978-80-86238-77-7, ISSN 2336-8128

Institution: Institute of Inorganic Chemistry AS ČR (web)
Document availability information: Fulltext is available at external website.
External URL: https://www.icct.cz/AngiologyKlon-ICCT/media/system/2018/ICCT-2018-Proceedings.pdf
Original record: http://hdl.handle.net/11104/0295557

Permalink: http://www.nusl.cz/ntk/nusl-394145

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Research > Institutes ASCR > Institute of Inorganic Chemistry
Conference materials > Papers
 Record created 2019-04-15, last modified 2019-04-15

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