Original title: Determination of stability constants of antamanide complexes with sodium and potassium ions by affinity capillary electrophoresis
Authors: Pangavhane, Sachin ; Böhm, S. ; Makrlík, E. ; Ruzza, P. ; Kašička, Václav
Document type: Papers
Conference/Event: Advances in Chromatography and Electrophoresis & Chiranal 2018, Olomouc (CZ), 20180129
Year: 2018
Language: eng
Abstract: Affinity capillary electrophoresis (ACE) was applied for quantitative investigation of the interactions between important biomolecule, cyclic decapeptide antamanide (AA), cycl[-Val(1)-Pro(2)-Pro(3)-Ala(4)-Phe(5)-Phe(6)-Pro(7)-Pro(8)-Phe(9)-Phe(10)-], and sodium and potassium cations in methanol. Apparent stability constants of AA complexes with these alkali metal ions were determined from the dependence of effective mobility of AA on the concentration of these ions in the background electrolyte by the non-linear regression analysis. The AA complexes with Na+ and K+ ions were found to be relatively weak, with the apparent stability constants 343 L/mol and 35 L/mol, respectively.
Keywords: affinity capillary electrophoresis; antamanide; binding constant
Project no.: GA15-01948S (CEP)
Funding provider: GA ČR
Host item entry: Advances in Chromatography and Electrophoresis & Chiranal 2018

Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0286862

Permalink: http://www.nusl.cz/ntk/nusl-386558

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Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
Conference materials > Papers
 Record created 2018-10-02, last modified 2019-10-20

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