Název: IL 57 - Sporadic colorectal cancer: From genetic make-up to complex phenotypic measurement, from risk determination to prognostic markers
Autoři: Vodička, Pavel ; Slyšková, Jana ; Pardini, B. ; Naccarati, A. ; Souček, P. ; Vodičková, Ludmila ; Vymetálková, Veronika ; Svoboda, Miroslav ; Foersti, A. ; Hemminki, K.
Typ dokumentu: Příspěvky z konference
Konference/Akce: Annual Meeting European Environmental Mutagenesis and Genomics Society /44./, Prague (CZ), 20150823
Rok: 2015
Jazyk: eng
Abstrakt: Colorectal carcinogenesis (CRC), is a complex process, resulting in both genomic and chromosomal instabilities. The valid theories of carcinogenesis accent either the role of somatic mutation or the surrounding microenvironment, however neither of them explains all features of cancer. Uncontrolled proliferation and genomic instability point to the DNA damage response and repair as to the key players. In the present study, we will overview several biomarkers in mapping heterogeneous complex CRC disease and providing prognostic information.\nVariants in genes involved in important pathways, such as DNA repair, cell cycle control, folate metabolism and methylation, insulin resistance and obesity, ABC transporters, selenoprotein genes, genes involved in inflammatory/immune response have shown various degree of association with CRC risk. We present also the data on mutations in high risk genes involved in colorectal carcinogenesis. Gene expression levels were determined in relevant pathways and complemented with other important parameters (epigenetic regulators of transcription by methylation). Additionally, the role of post-transcriptional regulation via miRNA or lncRNA was investigated in relation to the risk of CRC and the efficacy of chemotherapy. We have discovered several genetic and epigenetic markers affecting independently the prognosis of CRC. Functional DNA repair tests (complex phenotype) have been implemented as markers of individual susceptibility to sporadic CRC and its prognosis.\nAn application of the whole set of various biomarkers is inevitable to define the phenotypic landscape of the disease and to delineate the individual response to the therapy.\n
Klíčová slova: cancer risk determination; colorectal cancer; prognostic markers
Číslo projektu: NT14329 (CEP), NT14056 (CEP), LH13061 (CEP), GAP304/12/1585 (CEP), NT13424 (CEP)
Poskytovatel projektu: GA MZd, GA MZd, GA MŠk, GA ČR, GA MZd
Zdrojový dokument: 44th Annual Meeting EEMGS 2015. Final Programme and Abstract Book

Instituce: Ústav experimentální medicíny AV ČR (web)
Informace o dostupnosti dokumentu: Dokument je dostupný v příslušném ústavu Akademie věd ČR.
Původní záznam: http://hdl.handle.net/11104/0272305

Trvalý odkaz NUŠL: http://www.nusl.cz/ntk/nusl-361673


Záznam je zařazen do těchto sbírek:
Věda a výzkum > AV ČR > Ústav experimentální medicíny
Konferenční materiály > Příspěvky z konference